Crystalline polypeptides
AssigneeAmgen Inc.
InventorsTimothy Osslund, Christi Clogston, Shon Crampton, Randal Bass
Life of this patent
Estimating the term…
Abstract
The present invention relates to crystalline polypeptides and to methods of making them; to pharmaceutical compositions comprising crystalline polypeptides; and to therapeutic uses of such polypeptides and compositions.
Claims31
A crystal of etanercept.
A method of making a crystal of etanercept, wherein the method comprises combining a solution of etanercept polypeptide with a crystallization buffer comprising a salt.
A method of making a crystal of etanercept, wherein the method comprises combining a solution of etanercept polypeptide with co-solute means.
A method of administering to a subject an effective amount of crystalline etanercept.
A composition comprising etanercept in crystalline form and an ingredient selected from the group consisting of:
- acidifying means, active ingredients, propellant means, aggregation inhibiting means, denaturant means, alkalizing means, anticaking means, antifoaming means, antioxidant means, formulation buffering means, chelating means, coating means, coloring means, complex-forming means, dessicating means, filtering means, flavoring means, moisture-retaining means, ointment means, plasticizing means, carrier means, preserving means, solubilizing means, stabilizing means, means for dissolving, adsorbing means, stiffening means, suppository means, viscosity-increasing means, sweetening means, tablet binding means, diluent means, tablet disintegrant means, lubricating means, tonicity modifying means, vehicle means, water-repelling means, and sustained-release means.
Dependencies are inferred from the claim text.