Novel receptor-type phosphotyrosine phosphatase-alpha
AssigneeNew York University
InventorsJoseph Schlessinger, Jan Sap
Life of this patent
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Abstract
A novel receptor-type protein tyrosine phosphatase (RPTP) protein or glycoprotein and the DNA coding therefor is expressed in a wide variety of mammalian tissues. Included in this family of proteins are human RPTPα, human RPTPβ and human RPTPγ. The RPTP protein or glycoprotein may be produced by recombinant means. Antibodies to the proteins, methods for measuring the quantity of the proteins, methods for screening compounds, such as drugs, which can bind to the proteins and inhibit or stimulate their activity, are provided.
Claims4
1-10. (Canceled)
A method for detecting in a subject the presence of a nucleic acid molecule comprising a nucleotide sequence that (i) encodes a polypeptide having the amino acid sequence SEQ ID No:
- 1 or SEQ ID No:
- 3;
- (ii) is the complement of the nucleotide sequence of (i);
- or (iii) hybridizes under highly stringent conditions to the nucleic acid molecule of (i) or (ii), comprising:
- (a) contacting a cell or an extract thereof from said subject with a nucleic acid probe comprising at least a portion of the nucleic acid molecule of (i), (ii), or (iii) under highly stringent conditions;
- (b) measuring the hybridization of said probe to the nucleic acid molecules of said cell or an extract thereof, thereby detecting the presence of said nucleic acid molecule.
Dependencies are inferred from the claim text.