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US 2005/0032048 A1Published application
Analyzing polynucleotide sequences
AssigneeOxford Gene Technology Limited
InventorEdwin Southern
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AssigneeOxford Gene Technology Limited
InventorEdwin Southern
Estimating the term…
Abstract of the Disclosure This invention provides an apparatus and method for analyzing a polynucleotide sequence; either an unknown sequence or a known sequence. A support, e.g. a glass plate, carries an array of the whole or a chosen part of a complete set of oligonucleotides which are capable of taking part in hybridization reactions. The array may comprise one or more pairs of oligonucleotides of chosen lengths. The polynucleotide sequence, or fragments thereof, are labelled and applied to the array under hybridizing conditions. Applications include analyses of known point mutations, genomic fingerprinting, linkage analysis, characterization of mRNAs, mRNA populations, and sequence determination.
An apparatus for analysing a polynucleotide, the apparatus comprising an impermeable support segregated into at least two defined cells, the cells having oligonucleotides covalently attached thereto, wherein the sequence of the oligonucleotides of a first cell is different from the sequence of the oligonucleotides of a second cell.
An apparatus for analysing a polynucleotide, the apparatus comprising an impermeable glass plate with patches of microporous glass, the patches defining cells of an array, each cell having oligonucleotides covalently attached thereto, wherein the sequence of the oligonucleotides of a first cell is different from the sequence of the oligonucleotides of a second cell.
Dependencies are inferred from the claim text.