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OwnerDavid Carver, Timothy Prout +3inventors
InventorsDavid Carver, Timothy Prout, Hernita Ewald, Robyn Elliott, Paul Handreck
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A pharmaceutical formulation of paclitaxel and polyethoxylated castor oil is disclosed to be relatively acidified to a pH of less than 8.1 and preferably within a pH range of 5 to 7, inclusively. Ethanol is optionally included in the formulation which is adapted for use in a body for the treatment of cancer. A formulation method is disclosed and includes the step of mixing an acid with a carrier material, such as polyethoxylated castor oil, to form a carrier solution after which paclitaxel is added in an amount such that the resulting pH is less than 8.1 and preferably in a pH range of 5 to 7. Ethanol may optionally be slurried with the paclitaxel before mixing with the carrier solution. A variety of acidifying agents, a preferred one being anhydrous citric acid, are described.
A method for formulating a pharmaceutical paclitaxel composition such that the paclitaxel does not readily degrade, comprising the steps of:
A method for formulating a pharmaceutical paclitaxel composition such that the paclitaxel does not readily degrade, comprising the steps of:
A method of making an article of manufacture comprising a sealed container and a pharmaceutical paclitaxel formulation contained therein, said method comprising the steps of:
A method of making an article of manufacture comprising a sealed container and a pharmaceutical paclitaxel formulation contained therein, said method comprising the steps of:
A method for formulating a pharmaceutical paclitaxel composition such that the paclitaxel does not readily degrade, comprising
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