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AssigneeGenset S.A.
InventorsDaniel Cohen, Ilya Chumakov, Marta Blumenfeld, Sanober Shaikh, Marta Palicio-Barron, Hadi Abderrahim, Pascale Grel, Laurent Cavarec
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The invention relates to the use of PP2A/Bγ and to the use of a PP2A phosphatase comprising the PP2A/Bγ subunit for screening for modulators thereof. The use of these modulators for treating mental disorders such as bipolar disorder, schizophrenia and depression, and drugs comprising these modulators are further disclosed. The present invention further provides novel PP2A/Bγ subunits generated by alternative splicing events. The invention also discloses biallelic markers located in the gene encoding PP2A/Bγ and their use for diagnosing mental disorders.
An isolated polypeptide selected from the group consisting of:
Use of a PP2A/Bγ subunit as a target for screening candidate modulators.
Use of a PP2A phosphatase comprising a PP2A/Bγ subunit as a target for screening candidate modulators.
Use of modulator of a PP2A phosphatase comprising a PP2A/Bγ subunit for preparing a medicament for the treatment of a mental disorder.
Use of a gene therapy vector comprising a polynucleotide encoding a PP2A/Bγ subunit for preparing a medicament for the treatment of a mental disorder.
Use of a PP2A/Bγ subunit as a target for screening for natural binding partners.
A method of assessing the efficiency of a modulator of a PP2A phosphatase comprising a PP2A/Bγ subunit for the treatment of a mental disorder, said method comprising administering said modulator to an animal model for said mental disorder;
The method of any of 26 to 30, wherein said PP2A/Bγ subunit is a polypeptide of SEQ ID NO:
Use of at least one PP2A/Bγ-related biallelic marker for diagnosing whether an individual suffers from or is at risk of suffering from a mental disorder.
Use of at least one PP2A/Bγ-related biallelic marker for determining whether there is a significant association between said marker and a mental disorder.
A method of genotyping comprising the step of determining the identity of a nucleotide at a PP2A/Bγ-related biallelic marker or the complement thereof in a biological sample.
Use of a polynucleotide comprising a contiguous span of at least 12 nucleotides of SEQ ID NO:
Dependencies are inferred from the claim text.