Immunocytokine sequences and uses thereof
AssigneeEMD Lexigen Research Center Corp.
InventorsStephen D. Gillies, Kin-Ming Lo
Life of this patent
Estimating the term…
Abstract
The invention provides a family of antibodies that specifically bind the human cell surface glycosphingolipid GD2. The antibodies comprise modified variable regions, more specially, modified framework regions, which reduce their immunogenicity when administered to a human. The antibodies may be coupled to a therapeutic agent and used in the treatment of cancer.
Claims26
An antibody variable region comprising the amino acid sequence set forth in SEQ ID NO:
- 1:
An antibody variable region comprising the amino acid sequence set forth in SEQ ID NO:
- 2.
An antibody variable region comprising an amino acid sequence selected from the group consisting of amino acids 1-23 of SEQ ID NO:
- 1, amino acids 1-25 of SEQ ID NO:
- 2, and amino acids 67-98 of SEQ ID NO:
- 2, wherein the antibody variable region specifically binds to GD2.
Dependencies are inferred from the claim text.