US 2004/0203097 A1Published application

Kinases and phosphatases

OwnerHenry Yue, Dyung Aina M Lu +27inventors

InventorsHenry Yue, Dyung Aina M Lu, Yalda Azimzai, Li Ding, Ernestine A Lee, April J A Hafalia, Shanya D Becha, Y Tom Tang, Preeti G. Lal, Jennifer A Griffin, Rajagopal Gururajan, Jayalaxmi Ramkumar, Vicki S Elliott, Chandra S Arvizu, Wen Luo, Anita Swarnakar, Brendan M Duggan, Uyen K Tran, Narinder K Chawla, Ameena E Gandhi, Monique G Yao, Farrah A Khan, Mariah R Baughn, Mark L Borowsky, Yeganeh Zebarjadian, Thomas W Richardson, Joseph P Marquis, David Chien, Pei Jin

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Abstract

The invention provides human kinases and phosphatases (KPP) and polynucleotides which identify and encode KPP. The invention also provides expression vectors, host cells, antibodies, agonists, and antagonists. The invention also provides methods for diagnosing, treating, or preventing disorders associated with aberrant expression of KPP.

Claims28

Dependent claims

An isolated polypeptide selected from the group consisting of:

a) a polypeptide comprising an amino acid sequence selected from the group consisting of SEQ ID NO:1-14,
b) a polypeptide comprising a naturally occurring amino acid sequence at least 90% identical to an amino acid sequence selected from the group consisting of SEQ ID NO:1, SEQ ID NO:3-8, SEQ ID NO:10, and SEQ ID NO:14,
c) a polypeptide comprising a naturally occurring amino acid sequence at least 91% identical to the amino acid sequence of SEQ ID NO:13,
d) a polypeptide comprising a naturally occurring amino acid sequence at least 99% identical to an amino acid sequence selected from the group consisting of SEQ ID NO:9 and SEQ ID NO:11,
e) a polypeptide consisting essentially of a naturally occurring amino acid sequence at least 90% identical to the amino acid sequence of SEQ ID NO:12,
f) a biologically active fragment of a polypeptide having an amino acid sequence selected from the group consisting of SEQ ID NO:1-14, and
g) an immnunogenic fragment of a polypeptide having an amino acid sequence selected from the group consisting of SEQ ID NO:1-14.

4 more elements

An isolated polynucleotide selected from the group consisting of:

a) a polynucleotide comprising a polynucleotide sequence selected from the group consisting of SEQ ID NO:15-28,
b) a polynucleotide comprising a naturally occurring polynucleotide sequence at least 90% identical to a polynucleotide sequence selected from the group consisting of SEQ ID NO:15-28,
c) a polynucleotide complementary to a polynucleotide of a),
d) a polynucleotide complementary to a polynucleotide of b), and
e) an RNA equivalent of a)-d).

2 more elements

Dependencies are inferred from the claim text.

Facts

Application: 10/478,146Filed 18 Nov 2003
Priority: 24 May 2001
Published: 14 Oct 2004
Term ends: Not estimatedThe source records don’t support an estimate.

Classification10 codes

C12N 9/1205
Transferring phosphorus containing groups, e.g. kinases: phosphotransferases with an alcohol group as acceptor , e.g. protein kinases
A61P 3/00
Drugs for disorders of the metabolism
A61P 5/00
Drugs for disorders of the endocrine system
A61P 9/00
Drugs for disorders of the cardiovascular system

Family

Application60/293,665Us provisional application · filed 24 May 2001
Application60/298,712Us provisional application · filed 15 Jun 2001
Application60/303,418Us provisional application · filed 6 Jul 2001
Application60/306,967Us provisional application · filed 19 Jul 2001
Application60/308,183Us provisional application · filed 27 Jul 2001
Application60/343,007Us provisional application · filed 19 Dec 2001
Application60/357,675Us provisional application · filed 15 Feb 2002
Application60/376,988Us provisional application · filed 30 Apr 2002
US 2004/0203097 A1This patent

From the US filing history. Foreign family members aren’t listed.

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