Modulation of zinedin expression
AssigneeIsis Pharmaceuticals, Inc.
InventorsKenneth W. Dobie, Tamara Balac Sipes
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Abstract
Compounds, compositions and methods are provided for modulating the expression of zinedin. The compositions comprise oligonucleotides, targeted to nucleic acid encoding zinedin. Methods of using these compounds for modulation of zinedin expression and for diagnosis and treatment of disease associated with expression of zinedin are provided.
Claims24
A compound 8 to 80 nucleobases in length targeted to a nucleic acid molecule encoding zinedin, wherein said compound specifically hybridizes with said nucleic acid molecule encoding zinedin (SEQ ID NO:
- 4) and inhibits the expression of zinedin.
A method of screening for a modulator of zinedin, the method comprising the steps of:
- a. contacting a preferred target segment of a nucleic acid molecule encoding zinedin with one or more candidate modulators of zinedin, and
- b. identifying one or more modulators of zinedin expression which modulate the expression of zinedin.
A diagnostic method for identifying a disease state comprising identifying the presence of zinedin in a sample using at least one of the primers comprising SEQ ID NOs 5 or 6, or the probe comprising SEQ ID NO:
- 7.
Dependencies are inferred from the claim text.