Ophthalmologic irrigation solutions and method
AssigneeOmeros Corporation
InventorsGregory A. Demopulos, Pamela Pierce Palmer, Jeffrey M. Herz
Life of this patent
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Abstract
Solutions for perioperative intraocular application by continuous irrigation during ophthalmologic procedures are provided. These solutions include multiple agents that act to inhibit inflammation, inhibit pain, effect mydriasis (dilation of the pupil), and/or decrease intraocular pressure, wherein the multiple agents are selected to target multiple molecular targets to achieve multiple differing physiologic functions, and are included in dilute concentrations in a balanced salt solution carrier.
Claims54
A method for perioperatively inhibiting inflammation, inhibiting pain, effecting mydriasis, and/or decreasing intraocular pressure during an ophthalmologic procedure, comprising continuously irrigating ocular tissues during an ophthalmologic procedure with a solution including at least first and second agents in a liquid irrigation carrier, the first and second agents being selected to act on a plurality of differing molecular targets, each agent being selected from the physiologic functional classes of anti-inflammatory agents, analgesic agents, mydriatic agents and agents for decreasing intraocular pressure (“IOP reducing agents”), the second agent providing at least one physiologic function different than a function or functions provided by the first agent.
A method for perioperatively inhibiting inflammation, inhibiting pain, effecting mydriasis, and/or decreasing intraocular pressure during an ophthalmologic procedure;
- comprising irrigating ocular tissues during an ophthalmologic procedure with a solution including at least first and second agents in a liquid irrigation carrier, the first and second agents being selected to act on a plurality of differing molecular targets, each agent being selected from the physiologic functional classes of anti-inflammatory agents, analgesic agents, mydriatic agents and agents for decreasing intraocular pressure (“IOP reducing agents”), the second agent providing at least one physiologic function different than a function or functions provided by the first agent, each agent being included at a concentration of no more than 100,000 nanomolar.
A perioperative irrigation solution for use during ophthalmologic procedures to inhibit inflammation, inhibit pain, effect mydriasis, and/or decrease intraocular pressure during the procedure, including at least first and second agents in a liquid irrigation carrier, the first and second agents being selected to act on a plurality of differing molecular targets, each agent being selected from the physiologic functional classes of anti-inflammatory agents, analgesic agents, mydriatic agents and agents for decreasing intraocular pressure (“IOP reducing agents”), the second agent providing at least one physiologic function different than a function or functions provided by the first agent, each agent being included at a concentration of no more than 100,000 nanomolar.
Dependencies are inferred from the claim text.