Storage stable eplerenone formulation

A parenterally deliverable pharmaceutical composition comprising a solvent liquid and eplerenone, wherein at least a substantial portion of the eplerenone is present in the solvent liquid in dissolved and/or solubilized form, the composition has a pH of about 4.0 to about 5.5, and upon storage in a closed container maintained at 25° C. for a period of at least 180 days, said eplerenone constitutes at least about 96%, by weight, of eplerenone originally present in the composition.

A parenterally deliverable pharmaceutical composition comprising eplerenone in an amount of about 2.5 mg/ml to about 20 mg/ml, hydroxypropyl-β-cyclodextrin in an amount of about 10 mg/ml to about 110 mg/ml, at least one pharmaceutically acceptable buffering agent, at least one pharmaceutically acceptable isotonic agent, and water;

• wherein at least a substantial portion the eplerenone is present in dissolved and/or solubilized form and the composition has a pH of about 3.5 to about 6.0.