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AssigneeThe University of British Columbia
InventorsMartin Gleave, Paul S. Rennie, Kiyama Satoshi, Colleen Nelson
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Compositions and a method are provided for the treatment of prostate and other endocrine tumors in mammals, including humans, by administration of an antisense oligodeoxynucleotide (ODN) which is complementary to a portion of the gene encoding IGFBP-2. Using the Shionogi tumor model in vitro and in vivo, the administration of such an ODN was shown to reduce proliferation of tumor cells, and also to delay the progression to androgen independence. Thus, treatment of prostate and other hormone-regulated cancer in mammals, including humans, and delay of the progression of prostate tumors to androgen independence is accomplished by administering to the mammal a therapeutically effective amount of an antisense oligodeoxynucleotide which is complementary to a portion of the nucleic acid sequence encoding IGFBP-2 and which reduces the amount of IGFBP-2 in the treated cells.
A composition for treatment of hormone-regulated cancer comprising an antisense oligonucleotide which inhibits expression of IGFBP-2 by hormone-regulated tumor cells.
A method for treating a hormone-responsive cancer in an individual suffering from hormone-responsive cancer, comprising administering to the individual a composition comprising an antisense oligonucleotide which inhibits expression of IGFBP-2 by hormone-regulated tumor cells.
A method for delaying progression of hormone-regulated tumor cells to an hormone-independent state comprising the step of treating hormone-sensitive tumor cells with an antisense oligonucleotide which inhibits expression of IGFBP-2 by the tumor cells.
A method for inhibiting or delaying metastatic bony progression of an IGF-I sensitive tumor in an individual suffering from the IGF-I sensitive tumor, comprising the step of administering to the individual a composition comprising an antisense oligonucleotide which inhibits expression of IGFBP-2 by the tumor cells in an amount effective to inhibit expression of IGFBP-2 by the IGF-I sensitive cancer cells, thereby inhibiting or delaying metastatic bony progression of the tumor.
Dependencies are inferred from the claim text.