Agents affecting thrombosis and hemostasis
AssigneeCOR Therapeutics, Inc.
InventorsDavid L. Wolf, Uma Sinha
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Abstract
Analogs of blood factors which are transiently inactive are useful in treatment of diseases characterized by thrombosis. In addition, modified forms of activated blood factors that generate the active blood factor in serum but have extended half-lives are useful in treating hemophilic conditions. These modified forms of the blood factor may be acylated forms which are slowly deacylated in vivo.
Claims5
A procoagulant composition comprising a blood factor selected from the group consisting of Factor Xa, Factor IXa, and Factor VIIa, or a polypeptide fragment thereof, which blood factor has been transiently modified to have little or no enzymatic activity.
A blood factor selected from the group consisting of Factor Xa. Factor IXa, activated Protein C, and Factor VIIa, which has been modified to extend its half-life in serum wherein said modified form of blood factor generates active factor blood factor in the presence of serum.
A method to treat hemophilia in human subjects which method comprises administering to a subject in need of such treatment an amount of a blood factor selected from the group consisting of Factor Xa, Factor VIIa, and Factor IXa, which blood factor has been modified to extend its half-life in serum effective to offset the effects of hemophilia in said subject.
Dependencies are inferred from the claim text.