Echinocandin derivatives, their method of preparation and their application as anti-fungal agents

1) The compounds of formula (I) in all the possible isomer forms as well as their compounds:

• 18
• in which
• either R1 and R2 identical or different from one another, represent a hydrogen atom, a hydroxyl radical, an alkyl radical containing up to 8 atoms of linear, branched or cyclic carbon atoms, optionally interrupted by an oxygen atom optionally substituted by a hydrogen atom, an OH radical, an
• 19
• radical, a and b identical or different from one another,
• representing a hydrogen atom or an alkyl radical containing up to 8 carbon atoms, a and b able optionally to form a heterocycle with the nitrogen atom optionally containing one or several additional heteroatoms,
• or else R1 forms a double bond with the endocyclic carbon atom carrying the radical
• 20
• or else R2 represents an XRa radical,
• X representing an oxygen atom or an NH or N-alkyl radical containing up to 8 carbon atoms and Ra represents a hydrogen atom, a linear, branched or cyclic alkyl radical containing up to 8 carbon atoms optionally substituted by one or several hydrogen atoms, by one or several OH, CO2H, CO2alc radicals,
• an
• 21
• radical, a′ and b′ representing a hydrogen atom, an alkyl radical containing up to 8 carbon atoms, a′ and b′ able to form a heterocycle optionally containing one or several additional heteroatoms and/or by a heterocycle containing one or several heteroatoms where R2 represents a
• 22
• radical in which d, e, f and g represent a hydrogen atom or an alkyl radical containing up to 8 carbon atoms, f and g able moreover to represent an acyl radical containing up to 8 carbon atoms, e and f equally able to form a ring optionally containing one or several heteroatoms,
• R3 represents a hydrogen atom, a methyl or hydroxyl radical
• R4 represents a hydrogen atom or a hydroxyl radical
• R represents a linear, branched or cyclic chain containing up to 30 carbon atoms, optionally containing one or several heteroatoms, one or several heterocycles or a linear, branched or cyclic acyl radical containing up to 30 carbon atoms optionally containing one or several heteroatoms and/or one or several heterocycles,
• T represents a hydrogen atom, a methyl radical, a CH2CONH2, CH2C═N radical, a (CH2)2NH2 or (CH2)2Nalc+X− radical,
• X being a halogen atom and alc an alkyl radical containing up to 8 carbon atoms,
• Y represents a hydrogen atom, a hydroxyl radical or a halogen atom or an OSO3H radical or one of the salts of this radical,
• W represents a hydrogen atom or an OH radical,
• Z represents a hydrogen atom or a methyl radical,
• as well as the addition salts with the acids of the products of formula (I).