Treatment of skin with adenosine or adenosine analog
AssigneeUniversity of Massachusetts, a Massachusetts corporation
InventorsJames G. Dobson JR., Michael F. Ethier
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Abstract
Methods for enhancing the condition of non-diseased skin by application of compositions containing adenosine or an adenosine analog are disclosed. Also disclosed are methods for increasing DNA synthesis or protein synthesis in dermal cells, and methods for increasing dermal cell size, by application of compositions containing adenosine.
Claims53
A method for enhancing the condition of non-diseased skin of a mammal, comprising topically applying a therapeutically effective amount of a composition comprising adenosine or an adenosine agonist to non-diseased skin of said mammal.
A method for promoting healing of broken, non-diseased skin in a mammal, comprising topically administering a composition comprising a therapeutically effective amount of adenosine or an adenosine agonist to said mammal.
A method for increasing DNA synthesis in a dermal cell of non-diseased skin of a mammal, comprising topically administering a therapeutically effective amount of adenosine to a region of non-diseased skin of said mammal containing said dermal cell, wherein addition of said adenosine does not cause proliferation of said dermal cell.
A method of increasing protein synthesis in a dermal cell of non-diseased skin of a mammal, comprising topically administering a composition comprising a therapeutically effective amount of adenosine to a region of skin of said mammal containing said dermal cell, wherein addition of said adenosine does not cause proliferation of said dermal cell.
A method of increasing cell size in a dermal cell in non-diseased skin of a mammal, comprising topically administering a composition comprising a therapeutically effective amount of adenosine to a region of skin of said mammal containing said dermal cell, wherein addition of said adenosine does not cause proliferation of said dermal cell, wherein addition of said adenosine does not cause proliferation of said dermal cell.
A method for enhancing skin condition in a mammal, comprising
- providing fibroblasts from said mammal ex vivo,
- culturing said fibroblasts in the presence of adenosine;
- and
- reintroducing said fibroblasts into said mammal.
A method for increasing protein synthesis in a cultured skin fibroblast, comprising culturing said fibroblast in a culture medium comprising about 10−3 M to about 10−7 M adenosine.
A composition comprising 10−3 M to 10−7 M adenosine and an angiogenesis factor.
Dependencies are inferred from the claim text.