Compositions and methods for increasing the bioavailability of plant polyphenols

A pharmaceutical dosage form, comprising about 5 mg to about 500 mg of a composition comprising a xylanase and a glucanase.

A method for increasing a serum concentration of an aglycone in a subject in need thereof, comprising:

• administering to the subject a pharmaceutical dosage form comprising about 5 mg to about 500 mg of a composition comprising a xylanase and a glucanase.

A method for converting a glycoside into an aglycone in a digestive tract of a subject in need thereof, comprising:

• orally administering to the subject a composition comprising about 5 mg to about 500 mg endo-1,4-beta-xylanase and beta-glucanase concurrently with ingestion of the glycoside.

A method for converting genistin into genistein in a digestive tract of a subject in need thereof, comprising:

• orally administering to the subject a composition comprising about 5 mg to about 500 mg endo-1,4-beta-xylanase and beta-glucanase concurrently with ingestion of a soy food stuff.

A method for converting genistin into genistein in a digestive tract of a subject in need thereof, comprising:

• orally administering to the subject a composition comprising about 5 mg to about 500 mg of about two parts endo-1,4-beta-xylanase and about one part beta-glucanase concurrently with ingestion of a soy food stuff.

A pharmaceutical dosage form, comprising:

• about 5 mg to about 500 mg of about two parts endo-1,4-beta-xylanase, about one part beta-glucanase, and an optional pharmaceutically acceptable excipient.

A method for increasing a serum concentration of an aglycone in a subject in need thereof, comprising:

• administering to the subject a pharmaceutical dosage form comprising about 5 mg to about 500 mg of about two parts endo-1,4-beta-xylanase and about one part beta-glucanase.

A method for increasing a serum concentration of genistein in a subject in need thereof, comprising:

• administering to a subject a pharmaceutical dosage form comprising about 5 mg to about 500 mg of about two parts endo-1,4-beta-xylanase and about one part beta-glucanase.