Compositions comprising plant-derived polyphenolic compounds and inhibitors of reactive oxygen species and methods of using thereof
AssigneesThe Regents of the University of California, The United States of America as represented by the Department of Veterans Affairs
InventorsStephen J. Pandol, Anna Gukovskaya
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Abstract
Disclosed are methods for treating, preventing, or inhibiting cancer in a subject comprising administering at least one polyphenolic compound and at least one inhibitor of reactive oxygen species to the subject. The polyphenolic compound may be derived or isolated from plants. In some embodiments, the polyphenolic compound is a flavonoid. In other embodiments, the polyphenolic compound is a non-flavonoid. Other methods and kits are also disclosed as well as pharmaceutical compositions.
Claims34
A method of treating, preventing, or inhibiting cancer in a subject comprising administering at least one polyphenolic compound and at least one inhibitor of reactive oxygen species to the subject.
A method of inducing apoptosis in a tumor comprising contacting the tumor with at least one polyphenolic compound.
A method of activating caspase-3 comprising contacting a pro-caspase-3 with at least one polyphenolic compound.
A method of preventing, inhibiting, or modulating NF-κB activation in a cell comprising administering to the cell at least one polyphenolic compound and diphenylene iodonium, Tiron, N-acetylcysteine, an inhibitor of ROS production, NADPH oxidase, or a combination thereof.
A method of making a cancer cell susceptible to apoptosis induced by a polyphenolic compound comprising inhibiting NF-κB activity in the cell.
A method of making a cancer cell susceptible to apoptosis induced by a combination of a polyphenolic compound and diphenylene iodonium, Tiron, N-acetylcysteine, an inhibitor of ROS production, NADPH oxidase, or a combination thereof comprising inhibiting NF-κB activity in the cell.
A method of preventing, inhibiting, or attenuating the activation of Akt/PKB in a cell comprising administering to the cell at least one polyphenolic compound, at least one inhibitor of reactive oxygen species and at least one PI 3-kinase inhibitor, or at least one polyphenolic compound and diphenylene iodonium, Tiron, N-acetylcysteine, an inhibitor of ROS production, NADPH oxidase, or a combination thereof
A pharmaceutical composition comprising at least one polyphenolic compound, at least one inhibitor of reactive oxygen species, and a pharmaceutically acceptable carrier.
A kit for treating, preventing, or inhibiting cancer in a subject comprising at least one polyphenolic compound, at least one inhibitor of reactive oxygen species, and instructions for use.
A method of depolarizing a mitochondrial membrane comprising contacting the mitochondrial membrane with at least one polyphenolic compound.
A method of activating mitochondrial PTP comprising contacting the mitochondrial PTP with at least one polyphenolic compound.
A method of inducing mitochondrial cytochrome c release comprising contacting the mitochondrial membrane with at least one polyphenolic compound.
A method of activating PARP comprising contacting the mitochondrial PTP with at least one polyphenolic compound.
A method of causing apoptosis in a cancer cell comprising contacting the cancer cell with at least one polyphenolic compound and MG-1 32, a proteasomal inhibitor, or a combination thereof.
Dependencies are inferred from the claim text.