Genetic marker and test
OwnerRoderick Clifton-Blighinventor
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Abstract
A method of determining the susceptibility of a vertebrate to a bone-related disorder, the method comprising the steps of obtaining a DNA sample from the vertebrate; and analysing the DNA sample to determine whether the vertebrate has a polymorphism in the 1α-hydroxylase gene. Presence of the polymorphism indicates susceptibility of the vertebrate to the bone-related disorder.
Claims25
A method of determining the susceptibility of a vertebrate to a bone-related disorder, the method comprising the steps of:
- (i) obtaining a DNA sample from the vertebrate;
- and
- (ii) analysing the DNA sample to determine whether the vertebrate has a polymorphism in the 1α-hydroxylase gene, wherein presence of the polymorphism indicates susceptibility of the vertebrate to the bone-related disorder.
A method of diagnosing a bone-related disorder in a vertebrate, the method comprising the steps of:
- (i) obtaining a DNA sample from the vertebrate;
- and
- (ii) analysing the DNA sample to determine whether the vertebrate has a polymorphism in the 1α-hydroxylase gene, wherein presence of the polymorphism is an indicator of the bone-related disorder.
A kit for use in determining the susceptibility of a vertebrate to a bone-related disorder, the kit comprising at least one primer designed to specifically amplify the 1α-hydroxylase gene from the vertebrate and enable detection of the presence of a polymorphism in the 1α-hydroxylase gene, wherein the presence of the polymorphism indicates susceptibility of the vertebrate to the bone-related disorder.
Dependencies are inferred from the claim text.