Dermatologic composition using ultra-fine/micronized 1-ascorbic acid and other antioxidant ingredients in a stabilized anhydrous vehicle
OwnerJerry Whittemore, Robert Strominventors
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Abstract
This composition is a topical admixture of submicron vitamin C in percentages of 40.001%-70% by weight with exceptional biological activity, and exhibiting deep transdermal penetration. Using sodium ascorbate admixed with the 1-ascorbic acid reduces the epidermal irritation of high concentrations of total vitamin C. The sodium ascorbate naturally buffers the acidity of 100% 1-ascorbic acid Polyolprepolymer-2 enhances the epidermal penetration.
Claims14
1, A topical composition, comprising:
- particulate vitamin C in the amount 40.0001%-70% by weight;
- and
- an inert dimethicone topical serum, in the amount of 30-59.9999% by weight, wherein the silicone serum is in a sufficient amount to suspend the high amount of vitamin C, and the particulate vitamin C consists of chemically pure solids having a particle size of less than about 25 .mu.m.
2, The composition of claim 1, wherein the particulate vitamin C consists of essentially chemically pure 1-ascorbic acid.
3, The composition of claim 1, wherein the particulate vitamin C consists essentially of chemically pure sodium ascorbate.
4, The composition of claim 1, wherein the particulate vitamin C consists essentially of an admixture of 1-ascorbic acid and sodium ascorbate.
5, The composition of claim 1, wherein the particulate vitamin C consists of an admixture of 1-ascorbic acid, sodium ascorbate and fumed silica with the ratio of fumed silica to total vitamin C species being most preferably 0.14% by weight.
6, The composition of claim 1, wherein the dimethicone-serum is 100% dimethicone.
7, The composition of claim 1, wherein the dimethicone-serum is 100% dimethicone or dimethicone plus dimethiconol dissolved in cyclopentasiloxane.
8, The composition of claim 1, wherein the dimethicone-serum is replaced by 0.01-50% phenyl trimethicone, 0.01-50% cetyl dimethicone or 0.01-50% hexyl dimethicone.
9, The composition of claim 1, wherein the dimethicone serum is an admixture of dimethicone and dimethiconol.
10, The composition of claim 1, wherein the dimethicone-serum has the suspending agent fumed silica added in the amount of about 0.01-2% by weight, preferably 1% by weight.
11, The composition of claim 1, wherein the dimethicone serum is substantially free of copper ions which catalyzes oxidation of vitamin C species and breakdown of the lactone ring.
12, The composition of claim 1, wherein the dimethicone serum is substantially free of water and atmospheric oxygen, and in which the vitamin C species are totally insoluble.
13, The composition of claim 1, wherein about 1-2% by weight of the dimethicone-serum has been replaced by an admixture of anhydrous antioxidants including, but not limited to beta-glucon, beta-carotene, zanthalene, soy flavonoids, soy isoflavonoids, thiotic acid, tocopheryl acetate, tocopherol, lutein, green tea extract, Paraguay green tea extract.
14, The composition of claim 1, wherein the dimethicone base is admixed with polyolprepolymer-2 and, in which the percentage by weight of polyolprepolymer-2 in the low viscosity silicone base is 0.01% and 10%.