Methods of treating fat metabolism disorders
OwnerYing-Hue Leeinventor
Life of this patent
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Abstract
A method of determining whether a subject is suffering from or at risk for developing a disorder in fat metabolism. The method includes providing a sample from the subject and determining a Gsα expression level in the sample. If the Gsα expression level in the sample is different from that in a sample from a normal subject, it indicates that the subject is suffering from or at risk for developing a disorder in fat metabolism. Also disclosed are a method of identifying a compound for treating a disorder in fat metabolism, and a method and a composition for treating such a disorder.
Claims23
A method of determining whether a subject is suffering from or at risk for developing a disorder in fat metabolism, the method comprising:
- providing a sample from the subject, and
- determining a Gsα expression level in the sample,
- wherein the Gsα expression level in the sample, if different from that in a sample from a normal subject, indicates that the subject is suffering from or at risk for developing a disorder in fat metabolism.
A method of determining whether a subject is suffering from or at risk for developing a disorder in fat metabolism, the method comprising:
- providing a sample from the subject, and
- determining a Gsα activity level in the sample,
- wherein the Gsα activity level in the sample, if different from that in a sample from a normal subject, indicates that the subject is suffering from or at risk for developing a disorder in fat metabolism.
A method of identifying a compound for treating a disorder in fat metabolism, the method comprising:
- contacting a compound with a cell, and
- determining a Gsα expression level in the cell,
- wherein the Gsα expression level in the presence of the compound, if different from that in the absence of the compound, indicates that the compound is a candidate for treating a disorder in fat metabolism.
A method of identifying a compound for treating a disorder in fat metabolism, the method comprising:
- contacting a compound with a cell, and
- determining a Gsα activity level in the cell,
- wherein the Gsα activity level in the presence of the compound, if different from that in the absence of the compound, indicates that the compound is a candidate for treating a disorder in fat metabolism.
A method of treating a disorder in fat metabolism, the method comprising:
- identifying a subject suffering from or being at risk for developing a disorder in fat metabolism, and
- administering to the subject a composition to increase a Gsα level in the subject.
A pharmaceutical composition comprising a nucleic acid encoding a Gsα protein or a sequence complementary thereof, and a pharmaceutically acceptable carrier.
A pharmaceutical composition comprising a Gsα protein and a pharmaceutically acceptable carrier.
Dependencies are inferred from the claim text.