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OwnerPeter David Nightingale, Reginald Barry O'Neill +1inventors
InventorsPeter David Nightingale, Reginald Barry O'Neill, Robert Rhodes
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A method of manufacture of 3,5-bis(trifluoromethyl)bromobenzene, comprising the addition of a brominating reagent to a mixture of 3,5-bis(trifluoromethyl)benzene together with at least one of sulphuric acid or oleum in the absence of acetic acid. A method of production of 3,5-bis(trifluoromethyl)acetophenone comprising the reaction of 3,5-bis(trifluoromethyl)phenyl magnesium bromide with acetyl chloride in the presence of cuprous chloride. A method of production of 3,5-bis(trifluoromethyl)acetophenone comprising the steps of reacting 3,5-bis(trifluoromethyl)phenyl magnesium bromide with acetic anhydride, adding water, and recovering the product by azeotropic distillation. A method of removal of impurities including 3,5-bis(trifluoromethyl)acetate, 4-bromobutyl acetate and 4-chlorobutyl acetate from a preparation of 3,5-bis(trifluoromethyl)acetophenone, the method comprising heating the 3,5-bis(trifluoromethyl)acetophenone with a dilute solution of alkali. A method of production of 3,5-bis(trifluoromethyl)phenyl magnesium bromide comprising the reaction of 3,5-bis(trifluoromethyl)bromobenzene with magnesium in a solvent whilst maintaining the temperature of the reactants above 20° C. and below the reflux temperature of the solvent.
A method of manufacture of 3,5-bis(trifluoromethyl)bromobenzene, comprising the addition of a brominating reagent to a mixture of 1,3-bis(trifluoromethyl)benzene together with at least one of sulphuric acid or oleum in the absence of acetic acid.
A method according to any preceding claim, wherein at least 3 parts by weight of the acid and/or oleum is used to one part of the 1,3-bis(trifluoromethyl)benzene.
A method according to any preceding claim, wherein the reaction is carried out at a temperature in the range from −10° C. to 30° C.
A method according to any preceding claim further comprising at least one subsequent step of washing.
A method according to any preceding claim further comprising at least one purification step.
A method of production of 3,5-bis(trifluoromethyl)acetophenone comprising the reaction of 3,5-bis(trifluoromethyl)phenyl magnesium bromide with acetyl chloride in the presence of cuprous chloride.
A method of production of 3,5-bis(trifluoromethyl)acetophenone comprising the steps of reacting 3,5-bis(trifluoromethyl)phenylmagnesium bromide with acetic anhydride, adding water and recovering the product by azeotropic distillation.
A method of removal of impurities including 3,5-bis(trifluoromethyl)phenyl acetate, 4-bromobutyl acetate and 4-chlorobutyl acetate from a preparation of 3,5-bis(trifluoromethyl)acetophenone, the method comprising heating the 3,5-bis(trifluoromethyl)acetophenone with a dilute solution of alkali.
A method of production of 3,5-bis(trifluoromethyl)phenyl magnesium bromide comprising the reaction of 3,5-bis(trifluoromethyl)bromobenzene with magnesium in a solvent whilst maintaining the temperature of the reactants above 20° C. and below the reflux temperature of the solvent.
Dependencies are inferred from the claim text.