US 2004/0019225 A1 · Process for lactonization to produce simvastatin

Abstract

There is disclosed a process for the manufacture of simvastatin of Formula I 1 which comprises heating a compound, namely acid or ammonium salt of compound of Formula II, 2 where Z is H or NH4 in an organic solvent at a temperature of 130-140° C. 1 Name Residence Citizenship Ramesh 403, Janapriya Pramila Enclave India Dandala Uma Nagar, Kundanbagh, Begumpet Hyderabad - 500 016 (India) Sonny 505, Vishal Towers, A Block India Sebastian A.S. Raju Nagar, Kukatpally, Hyderabad - 500 072 (India) Sanapureddy 4/134, Pakeerpalli, India Jagan Mohan Sankarapuram (post) Reddy Cuddapah - 516 002 (India) Meenakshisunderam D-1, Hidden Treasure Apartments India Sivakumaran Near Ayyappa Swami Temple Lane Somajiguda, Hyderabad - 500 082 (India)

Claims8

Dependent claims

A process for lactonization to produce simvastatin of Formula I

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which comprises the steps of:
starting with a compound, namely acid or ammonium salt of compound of Formula II
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where Z is H or NH4,
cyclizing the said compound of Formula II in an organic solvent at a temperature greater than 110° C.,
distilling off all solvent to produce simvastatin of Formula I.

4 more elements

Dependencies are inferred from the claim text.

Process for lactonization to produce simvastatin

Life of this patent

Process for lactonization to produce simvastatin

Life of this patent

Abstract

Claims8