Derivatives of monosaccharides as cell adhesion inhibitors

The method of preventing, inhibiting or suppressing cell adhesion in an animal comprising administering to said animal, a compound having the structure of Formula I:

• 15
• and its pharmaceutically acceptable salts, esters, enantiomers, diastereomers, N-oxides, amides, prodrugs, metabolites, or polymorphs, wherein R is C1 to C15 alkyl, alkene, alkyne (straight chain or branched), aryl, substituted aryl or alkylaryl and R1 is phenyl, o,- m- or p-chlorophenyl, tolyl, methoxyphenyl or nitrophenyl and R2 is H, pyrrolidinyl, piperidinyl, morphilinyl or hexamethyleneimino or a radical of the formula NHR3, wherein R3 is C1 to C15 alkyl, alkene or alkyne (straight chain or branched) or a radical of Formula III:
• 16
• in which n is a whole number up to 5 and
• 17
• is a five-, six- or seven-membered heterocyclic ring containing one or more heteroatoms.

A method for treating an animal suffering from bronchial asthma, rheumatoid arthritis, multiple sclerosis, type I diabetes, psoriasis, allograft rejection, and other inflammatory and/or autoimmune disorders in an animal comprising administering to said animal a compound of the structure of Formula I:

• 19
• wherein R is C1 to C1-5 alkyl, alkene, alkyne (straight chain or branched), aryl, substituted aryl or alkylaryl and R1 is phenyl, o,- m- or p-chlorophenyl, tolyl, methoxyphenyl or nitrophenyl and R2 is H, pyrrolidinyl, piperidinyl, morphilinyl- or hexamethyleneimino or a radical of formula NHR3, wherein R3 is C1 to C15 alkyl, alkene or alkyne (straight chain or branched) or a radical of Formula III:
• 20
• in which n is a whole number up to 5 and
• 21
• is a five-, six- or seven-membered heterocyclic ring containing one or more heteroatoms.