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US 2004/0019092 A1Published application
Non-peptide somatostatin receptor ligands
OwnerDaniel Berney, Robin Breckenridge +4inventors
InventorsDaniel Berney, Robin Breckenridge, Peter Neumann, Gideon Shapiro, Max Peter Seiler, J. Troxler Thomas
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Abstract
The present invention provides compounds of formula (I), wherein X, Y, R1, R2, R3, and R4 are as defined in the description, and the preparation therof. The compounds of the formula bind to somatostatin receptiors and are useful as pharmaceuticals. 1
Claims7
A compound of formula:
- 8
- wherein R1 is —(CH2)5—NH2;
- R2 is —SO2-3-(CN)-4-(p-NH2-Ph-O)-Ph;
- R3 is H;
- and R4 is R3-CH2-3-indolyl;
- X and Y are O.
3 more elements
A compound of formula:
- 9
- wherein R1 is —(CH2)5—NH2,;
- R2 is —SO2-3-[(Me)2NCO]-4-(3-Cl-4-OH-Ph-O)-Ph;
- R3 is H;
- and R4 is —CH2-3-(7-Me-indolyl);
- X and Y are O.
3 more elements
A compound of formula:
- 10
- wherein R1 is —(CH2)5—NH2,;
- R2 is —SO2-3-(CN)-4-(3-Cl-4-OH-Ph-O)-Ph;
- R3 is H;
- and R4 is —CH2-3-(7-Me-indolyl);
- X and Y are O.
3 more elements
A compound of formula:
- 11
- wherein R1 is —(CH2)5—NH2,;
- R2 is —SO2-3-(CH2NH2)-4-(p-OH-Ph-O)-Ph;
- R3 is H;
- and R4 is —CH2-3-(7-Me-indolyl);
- X and Y are O.
3 more elements
A compound of formula:
- 12
- wherein R1 is —(CH2)5—NH2, R2 is —SO2-3-[(Me)2NCO]-4-(p-OH-Ph-O)-Ph-;
- R3 is H;
- and R4 is —CH2-3-(7-Me-indolyl);
- X and Y are O.
2 more elements
A compound of formula:
- 13
- wherein R1 is —(CH2)4—C(CH3)2—NH2, R2 is —SO2-3-[(Me)2NCO]-4-(3-Cl-4-OH-Ph-O)-Ph;
- R3 is H;
- and R4 is —CH2-3-(7-Me-indolyl);
- X and Y are O.
2 more elements
A compound of formula:
- 14
- wherein R1 is —(CH2)5—NH2,;
- R2 is —SO2-3-[(Me)2NCO]-4-[3-Cl-4-(OCOCH(NH2)(CH2)4NH2)—Ph-O]-Ph;
- R3 is H;
- and R4 is —CH2-3-indolyl;
- X and Y are O.
3 more elements
Dependencies are inferred from the claim text.