Ophthalmic antibiotic drug formulations containing a cyclodextrin compound and cetyl pyridinium chloride

A method of treating an eye infection in a subject, comprising administering to the subject a therapeutically effective dose of a pharmaceutical composition suitable for topical administration to an eye, comprising:

• an antibiotic drug in an antibiotic concentration effective for treatment and/or prophylaxis of a gram-positive bacterial infection of at least one tissue of the eye;
• a pharmaceutically acceptable cyclodextrin compound in a cyclodextrin concentration sufficient to maintain the drug in solution;
• and
• cetyl pyridinium chloride.

A pharmaceutical composition suitable for topical administration to an eye, comprising:

• (a) linezolid in a concentration effective for treatment and/or prophylaxis of a gram-positive bacterial infection of at least one tissue of the eye;
• (b) a pharmaceutically acceptable cyclodextrin compound in a cyclodextrin concentration sufficient to maintain the linezolid in solution;
• and
• (c) cetyl pyridinium chloride.