Antisense modulation of IL-1 receptor-associated kinase-4 expression
OwnerC. Frank Bennett, Susan M. Freierinventors
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Abstract
Antisense compounds, compositions and methods are provided for modulating the expression of IL-1 receptor-associated kinase-4. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding IL-1 receptor-associated kinase-4. Methods of using these compounds for modulation of IL-1 receptor-associated kinase-4 expression and for treatment of diseases associated with expression of IL-1 receptor-associated kinase-4 are provided.
Claims20
A compound 8 to 50 nucleobases in length targeted to a nucleic acid molecule encoding IL-1 receptor-associated kinase-4, wherein said compound specifically hybridizes with said nucleic acid molecule encoding IL-1 receptor-associated kinase-4 and inhibits the expression of IL-1 receptor-associated kinase-4.
A compound 8 to 50 nucleobases in length which specifically hybridizes with at least an 8-nucleobase portion of an active site on a nucleic acid molecule encoding IL-1 receptor-associated kinase-4.
Dependencies are inferred from the claim text.