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OwnerYoshihide Hayashizaki, Mamoru Kamiya +4inventors
InventorsYoshihide Hayashizaki, Mamoru Kamiya, Tomohiko Suzuki, Hiroe Hirokawa, Kaoru Nakao, Toshiaki Tanaka
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An object of the present invention is to find novel genes that relate to, but are not limited to, pain, such as neuropathic pain, shingles pain, and post-herpetic neuralgia, and are induced upon pain, and provide a reagent, method and pharmaceutical for diagnosing and assessing pain, or preventing and treating pain. The present invention provides polynucleotides having nucleotide sequences composing novel genes, polypeptides encoded by the polynucleotides, and partial peptides thereof, recombinant vectors containing the polynucleotides, transformants having the recombinant vectors, antibodies against the polypeptides or partial peptides thereof, and the like, which are utilizable in biology, medicine, veterinary medicine, and the like. Further, the present invention provides a method for producing the polypeptides, compounds whose target molecules are the polynucleotides or the polypeptides, and pharmaceuticals containing the polypeptides or the partial peptides thereof, compounds whose target molecules are the polynucleotides or the polypeptides, or antibodies against the polypeptides. They are used particularly to diagnose and assess pain, or prevent and treat pain. Further, the present invention provides a method for identifying compounds and the like using these polynucleotides, polypeptides, or the partial peptides thereof, or salts thereof as a target molecule to prevent and treat pain, a method for using the identified compound to prevent and treat pain, a method for diagnostic monitoring a patient to be subjected to clinical evaluation for pain treatment, a method for monitoring the clinical efficiency of the compound, and a method for identifying a patient having diathesis of pain.
An isolated polynucleotide, comprising a nucleotide sequence selected from the group consisting of SEQ ID NOS:
An isolated polynucleotide, which hybridizes under stringent conditions to the polynucleotide consisting of the nucleotide sequence selected from the group consisting of SEQ ID NOS:
An isolated polynucleotide, comprising a nucleotide sequence having at least 70% homology with the nucleotide sequence selected from the group consisting of SEQ ID NOS:
An isolated polynucleotide, comprising a nucleotide sequence encoding a polypeptide consisting of an amino acid sequence selected from the group consisting of SEQ ID NOS:
An isolated polypeptide, comprising the amino acid sequence selected from the group consisting of SEQ ID NOS:
An isolated polypeptide, which has at least 70% homology with the amino acid sequence selected from the group consisting of SEQ ID NOS:
A method for screening for a compound that suppresses or enhances an expression of a polynucleotide, wherein said polynucleotide hybridizes under stringent conditions to the polynucleotide consisting of the nucleotide sequence selected from the group consisting of SEQ ID NOS:
A kit for screening for a compound that suppresses or enhances an expression of a polynucleotide, wherein said polynucleotide hybridizes under stringent conditions to the polynucleotide consisting of the nucleotide sequence selected from the group consisting of SEQ ID NOS:
A kit for screening for a compound that acts on a polypeptide by using the polypeptide, wherein said polypeptide is encoded by the polynucleotide which hybridizes under stringent conditions to the polynucleotide consisting of the nucleotide sequence selected from the group consisting of SEQ ID NOS:
Dependencies are inferred from the claim text.