Redox therapy for tumors
OwnerArnold Hoffman, Lee M. Spetner +1inventors
InventorsArnold Hoffman, Lee M. Spetner, Michael Burke
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Abstract
The invention provides methods and compositions for treatment of tumors comprising administering to subject bearing a tumor an effective amount of at least one agent that decreases the [GSH]2/[GSSG] ratio in the malignant cells of said tumor, wherein said at least one agent is administered continuously to said patient for a period of time within the range of from about 15 to about 75 hours.
Claims16
A method of treating a tumor in a subject, which comprises administering to said subject an effective amount of at least one agent that decreases the [GSH]2/[GSSG] ratio in the malignant cells of said tumor, wherein said at least one agent is administered continuously to said patient for a period of time within the range of from about 15 to about 75 hours.
A method of treating a tumor in a subject, which comprises administering to said subject an effective amount of a synergistic combination of at least two agents that decrease the [GSH]2/[GSSG] ratio in the malignant cells of said tumor, wherein said agents are selected from the classes consisting of:
- (i) an agent that oxidizes GSH, or a precursor thereof;
- (ii) an agent that forms an adduct or a conjugate with GSH, or a precursor thereof;
- (iii) an agent that inhibits the GCS enzyme;
- and
- (iv) an agent that inhibits the glutathione reductase (GR) enzyme,
Dependencies are inferred from the claim text.