Semaphorin-like proteins and methods of using same

A method of inhibiting cell migration comprising introducing to a cell a composition comprising a nucleic acid having at least 95% sequence identity to SEQ ID NOs:

• 13, 15, 17, 19, 21, 23, 25, 27, 29, 31, 33, 35, 37, 39, 41, 43, 45,47,49,51,53, or 55.

The method of claim 16, wherein the cancer cell is a neuroblastoma cell, a renal carcinoma cell, a fibrosarcoma cell, a rhabdosarcoma cell or a pancreatic cancer cell.

A method of inhibiting angiogenesis of a tissue comprising contacting the tissue with a composition comprising a polypeptide having at least 95% sequence identity to SEQ ID NOs:

• 14, 16, 18, 20, 22, 24, 26, 28, 30, 32, 34, 36, 38, 40, 42, 44, 46, 48, 50, 52, 54, or 56.

A method of inhibiting angiogenesis of a tissue introducing to a cell a composition comprising a nucleic acid having at least 95% sequence identity to a SEQ ID NOs:

• 13, 15, 17, 19, 21, 23, 25, 27, 29, 31, 33, 35, 37, 39, 41, 43, 45, 47, 49, 51, 53, 55, 57, or 59.

A method of inhibiting actin filament formation in a cell by contacting the cell with a composition comprising a polypeptide having at least 95% sequence identity to SEQ ED NOs:

• 14, 16, 18, 20, 22, 24, 26, 28, 30, 32, 34, 36, 38, 40, 42, 44, 46, 48, 50, 52, 54, or 56.

A method of inhibiting actin filament formation comprising introducing to a cell a composition comprising a nucleic acid having at least 95% sequence identity to SEQ ID NOs:

• 13, 15, 17, 19, 21, 23, 25, 27, 29, 31, 33, 35, 37, 39, 41, 43, 45, 47, 49, 51, 53, or 55.

A method of preventing or alleviating a symptom of an angiogenic related disorder comprising administering to a subject a composition comprising a polypeptide having at least 95% sequence identity to SEQ ID NOs:

• 14, 16, 18, 20, 22, 24, 26, 28, 30, 32, 34, 36, 38, 40, 42, 44, 46, 48, 50, 52, 54, or 56.

A chimeric protein comprising a first polypeptide comprising a NOVX polypeptide and second polypeptide.

A composition comprising SEQ ID NO:

• 50 or 54.