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AssigneeThe Board of Trustees of the Leland Stanford Junior University
InventorsCatriona Helen M. Jamieson, Laurie Elizabeth Ailles, Tannishtha Reya, Irving Weissman
Estimating the term…
Methods and compositions are provided for the identification of stem cells and cancer stem cells. β-catenin is also identified as a target for the development of therapeutic moieties against hematopoietic tumors, i.e. leukemia and lymphoma cells, which may include screening assays directed at β-catenin, or members of the β-catenin signaling pathway. Cellular proliferation in hematopoietic cells can be altered by introducing stabilized β-catenin into a hematopoietic cell that is altered in its ability to undergo apoptosis but which is not fully transformed. The immortalized cells are useful in screening assays, and in the analysis of pathways by which hematopoietic cells undergo transformation.
A method for the identification of stem cells, the method comprising:
A method for diagnosis or characterization of a hematopoietic hyperproliferative disorder, the method comprising:
A method for increasing the lifespan of a mammalian hematopoietic cell, said method comprising:
Dependencies are inferred from the claim text.