Integrin expression inhibitors

An integrin expression inhibitor comprising, as an active ingredient, a sulfonamide compound represented by the formula (I), a pharmacologically acceptable salt thereof or a hydrate of them.

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• In the formula, B represents a C6-C10 aryl ring or a 6- to 10-membered heteroaryl ring which may have a substituent and in which a part of the ring may be saturated;
• K represents a single bond, —CH═CH— or —(CR4bR5b)mb— (where R4b and R5b are the same as or different from each other and each represents hydrogen atom or a C1-C4 alkyl group;
• and mb means an integer of 1 or 2);
• R1 represents hydrogen atom or a C1-C6 alkyl group;
• Z represents a single bond or —CO—NH—;
• and R represents a C6-C10 aryl ring or a 6- to 10-membered heteroaryl ring which may have a substituent and in which a part of the ring may be saturated, respectively.

An integrin expression inhibitor comprising, as an active ingredient, a sulfonamide compound represented by the formula (Ia), a pharmacologically acceptable salt thereof or a hydrate of them.

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• In the formula, the Aa ring a monocyclic or bicyclic aromatic ring which may have a substituent;
• the Ba ring represents an optionally substituted 6-membered cyclic unsaturated hydrocarbon or unsaturated 6-membered heterocycle containing one nitrogen atom as a heteroatom;
• the Ca ring represents an optionally substituted 5-membered heterocycle containing 1 or 2 nitrogen atoms;
• R1a represents hydrogen atom or a C1-C6 alkyl group;
• Wa represents a single bond or —CH═CH—;
• Ya represents carbon atom or nitrogen atom;
• and Za represents —N(R2a)—(wherein R2a means hydrogen atom or a lower alkyl group) or nitrogen atom, respectively.

An integrin expression inhibitor comprising, as an active ingredient, a sulfonamide-containing heterocyclic compound represented by the formula (Ib), a pharmacologically acceptable salt thereof or a hydrate of them.

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• In the formula, Ab represents hydrogen atom, a halogen atom, hydroxyl group, a C1-C4 alkyl or alkoxy group which may be substituted with a halogen atom, cyano group, —(CO)kbNR2bR3b (wherein R2b and R3b are the same as or different from each other and each means hydrogen atom or a C1-C4 alkyl group which may be substituted with a halogen atom;
• and kb means 0 or 1), a C2-C4 alkenyl or alkynyl group which may have a substituent, or a phenyl or phenoxy group which may have a substituent selected from the following group A;
• Bb means an aryl group or monocyclic heteroaryl group which may have a substituent selected from the following group A, or the following formula:
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• (wherein the ring Qb means an aromatic ring which may have one or two nitrogen atoms;
• and the ring Mb means a C5-C12 unsaturated monocycle or heterocycle having a double bond in common with the ring Qb. The ring may have 1 to 4 hetero atoms selected from nitrogen atom, oxygen atom and sulfur atom, the ring Qb and the ring Mb may jointly have nitrogen atom, and the ring Qb and the ring Mb may have a substituent selected from the following group A);
• Kb means a single bond or —(CR4bR5b)mb—(wherein R4b and R5b are the same as or different from each other and each means hydrogen atom or a C1-C4 alkyl group;
• and mb means an integer of 1 or 2);
• Tb, Wb, Xb and Yb are the same as or different from each other and each means ═C(Db)—(wherein Db represents hydrogen atom, a halogen atom, hydroxyl group, a C1-C4 alkyl or alkoxy group which may be substituted with a halogen atom, cyano group, —(CO)nbNR6bR7b (wherein R6b and R7b are the same as or different from each other and each means hydrogen atom or a C1-C4 alkyl group which may be substituted with a halogen atom;
• and nb means 0 or 1) or a C2-C4 alkenyl or alkynyl group which may have a substituent, respectively) or nitrogen atom;
• Ub and Vb are the same as or different from each other and each means ═C(Db)—(wherein Db has the same meaning as above), nitrogen atom, —CH2—, oxygen atom or —CO—;
• Zb means a single bond or —CO—NH—;
• R1b means hydrogen atom or a C1-C4 alkyl group;
• and means a single bond or a double bond.
• Group A:
• a halogen atom, hydroxyl group, a C1-C4 alkyl or alkoxy group which may be substituted with a halogen atom, cyano group, —R8bR9bN(NH)pb—(wherein R8b and R9b are the same as or different from each other and each means hydrogen atom or a C1-C4 alkyl group which may be substituted with a halogen atom;
• and pb means 0 or 1. Further, R8b and R9b may form a 5- or 6-membered ring together with the nitrogen atom to which they are bound, and the ring may further contain nitrogen atom, oxygen atom or sulfur atom, and also may have a substituent.), an aminosulfonyl group which may be substituted with a mono- or di-C1-C4 alkyl group, a C1-C8 acyl group which may have a substituent, a C1-C4 alkyl-S(O)sb—C1-C4 alkylene group (wherein sb means an integer of 0, 1 or 2), a phenylsulfonylamino group which may have a C1-C4 alkyl or a substituent, —(CO)qbNR10bR11b (wherein R10b and R11b are the same as or different from each other and each means hydrogen atom, or a C1-C4 alkyl group which may substituted with an amino group which may be substituted with a halogen atom or a C1-C4 alkyl group;
• and qb means 0 or 1), or an aryl group or heteroaryl group which may have a substituent.