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US 2004/0018178 A1Published application
Stem cell-derived endothelial cells modified to disrupt tumor angiogenesis
AssigneeAdvanced Cell Technology, Inc.
InventorMichael West
Life of this patent
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Abstract
The present invention provides cloned, genetically modified, endothelial cells, and the stem cells from which they are derived, which are produced by somatic cell nuclear transfer. The invention further provide novel therapeutic methods in which such cells are administered to a patient with tumors to inhibit and/or disrupt angiogenesis of the tumors, thereby inhibiting tumor growth and killing tumor cells.
Claims18
A method for decreasing tumor mass in a cancer patient, comprising:
- (a) ablating bone marrow from said patient, and
- (b) grafting endothelial cell precursors (ECPs) or precursors thereof into said patient such that a decrease in tumor mass results, wherein said ECPs or precursors thereof are genetically modified to mediate a decrease in tumor mass.
Dependencies are inferred from the claim text.