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US 2004/0010036 A1Published application
N,N, -Substituted s-Aryl-Isothioureas, N,N,N, -Substituted s-Aryl-Isothioureas and combinatorial libraries thereof
OwnerBoris Rogovoy, Vladimir Vvedenskiy +4inventors
InventorsBoris Rogovoy, Vladimir Vvedenskiy, Xiaohong Cai, Christophe Chassaing, Alan R. Katritzky, Behrouz Forood
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Abstract
The present invention relates to novel N,N,-Substituted S-Aryl-Isothioureas, and N,N,N′-Substituted S-Aryl-Isothioureas and combinatorial libraries thereof, as well as methods of preparing N,N,-Substituted S-Aryl-Isothioureas, and N,N,N′-Substituted S-Aryl-Isothiourea derivative compounds.
Claims18
A combinatorial library of two or more compounds of the formula:
- 203
- wherein
- R1 and R6 are independently selected from the group consisting of H, —OH, halide, C1 to C7 alkoxy, substituted C1 to C7 alkoxy, amino, substituted amino, acylamino, substituted acylamino, carboxyl, carboxylate ester, carboxamide, substituted carboxamide, phenyl, substituted phenyl, C1 to C6 alkyl, C1 to C6 substituted alkyl, C1 to C6 alkenyl, C1 to C6 substituted alkenyl, C1 to C6 alkynyl, C1 to C6 substituted alkynyl, nitro, thiol, thioether, and substituted thioether, or R1 and R6 taken together form a ring fused to the phenyl to form a naphthyl ring,
- R2 is selected from the group consisting of C1 to C6 alkyl, C1 to C6 substituted alkyl, benzyl, substituted benzyl, phenylalkyl and substituted phenylalkyl,
- R3 is selected from the group consisting of phenyl, substituted phenyl naphthyl and substituted naphthyl;
- and
- R4 is selected from the group consisting of H, and an unsubstituted or a substituted phenyl, wherein said substituted phenyl is substituted with at least one substituent selected from the group consisting of:
- halo, C1 to C6 alkyl, C1 to C6 alkoxy, nitro, C1 to C6 substituted alkyl, C1 to C6 substituted alkoxy, C1 to C6 alkylthio, phenyl, cyano, benzyl, substituted benzyl, naphthyl, and substituted naphthyl.
5 more elements
A compound of the formula:
- 204
- wherein
- R1 and R6 are independently selected from the group consisting of H, —OH, halide, C1 to C7 alkoxy, substituted C1 to C7 alkoxy, amino, substituted amino, acylamino, substituted acylamino, carboxyl, carboxylate ester, carboxamide, substituted carboxamide, phenyl, substituted phenyl, C1 to C6 alkyl, C1 to C6 substituted alkyl, C1 to C6 alkenyl, C1 to C6 substituted alkenyl, C1 to C6 alkynyl, C1 to C6 substituted alkynyl, nitro, thiol, thioether, and substituted thioether,or R1 and R6 taken together form a ring fused to the phenyl to form a naphthyl ring,
- R2 is selected from the group consisting of C1 to C6 alkyl, C1 to C6 substituted alkyl, benzyl, substituted benzyl, phenylalkyl and substituted phenylalkyl,
- R3 is selected from the group consisting of phenyl, substituted phenyl, naphthyl and substituted naphthyl;
- and
- R4 is selected from the group consisting of H, and an unsubstituted or a substituted phenyl, wherein said substituted phenyl is substituted with at least one substituent selected from the group consisting of:
- halo, C1 to C6 alkyl, C1 to C6 alkoxy, nitro, C1 to C6 substituted alkyl, C1 to C6 substituted alkoxy, C1 to C6 alkylthio, phenyl, cyano, benzyl, substituted benzyl, naphthyl, and substituted naphthyl.
5 more elements
Dependencies are inferred from the claim text.