Self-assembly of peptide-amphiphile nanofibers under physiological conditions
AssigneeNorthwestern University
InventorsSamuel I. Stupp, Jeffrey D. Hartgerink, Elia Beniash
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Abstract
Peptide amphiphile compounds, compositions and methods for self-assembly or nanofibrous network formation under neutral or physiological conditions.
Claims33
A sol-gel system comprising a peptide amphiphile compound having a bioactive epitope sequence, a hydrophobic component, and a net charge at substantially physiological pH;
- and a reagent to induce gelation of said amphiphile compound.
A method of peptide amphiphile nanofiber formation, said method comprising:
- providing an aqueous medium including a peptide amphiphile compound having a peptide component with a bioactive epitope sequence, and a hydrophobic component, said hydrophobic component sufficient to afford nanofiber formation of said compound;
- placing said medium on a surface;
- and
- removing said aqueous component from said medium.
A method of peptide amphiphile nanofiber formation, said method comprising:
- providing an aqueous medium comprising a peptide amphiphile compound having a bioactive epitope sequence, a hydrophobic component, and a net charge at substantially physiological pH;
- and
- introducing a reagent to said medium to induce nanofiber formation.
A peptide amphiphile composition comprising a first peptide component comprising a hydrophobic moiety and a first amino acid sequence, said sequence further comprising a first bioactive epitope sequence;
- and a second peptide component comprising a hydrophobic moiety and a second amino acid sequence, said sequence further comprising a second bioactive epitope sequence, said first amino acid sequence having a net charge at a physiological pH, and said second amino acid sequence having a net charge at a physiological pH opposite said net charge of said first amino acid sequence.
Dependencies are inferred from the claim text.