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US 2004/0001872 A1Published application
Biodegradable block copolymeric compositions for drug delivery
AssigneeNovartis AG
InventorsChung Shih, Gaylen M. Zentner
Life of this patent
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Abstract
An improved drug delivery composition and method of use is disclosed. The composition comprises one or more biodegradable block copolymer drug carriers; and a reconstitution enhancing and enabling agent comprising polyethylene glycol (PEG), a PEG derivative or a mixture of PEG and a PEG derivative. The composition can be administered as is or after being be dissolved or rapidly reconstituted in an aqueous vehicle to afford a homogeneous solution or uniform colloidal systems.
Claims41
A composition comprising:
- 1) one or more biodegradable block copolymer drug carriers comprising A-B, A-B-A or B-A-B block copolymers having a total weight average molecular weight of 1000 to 100,000 Daltons, wherein the A block is a biodegradable polyester or poly(ortho ester) and the B block is polyethylene glycol(PEG), and the weight percentage of the A block is between 20% to 99% and the weight percentage of the B block is between 1% to 80%;
- and
- 2) a liquid polyethylene glycol(PEG), a PEG derivative, or a mixture of PEG and a PEG derivative, said PEG or PEG derivative having a molecular weight of 150 to 1100 Daltons;
- wherein the biodegradable block copolymeric drug carrier is soluble in the liquid PEG, PEG derivatives, or mixtures of PEG and PEG derivatives.
1 more element
A composition comprising:
- 1) one or more biodegradable block copolymer drug carriers comprising A-B, A-B-A or B-A-B block copolymers having a total weight average molecular weight of 2000 to 8000 Daltons, wherein the A block is a biodegradable polyester or poly(ortho ester) and the B block is polyethylene glycol(PEG), and the weight percentage of the A block is between 50.1% to 83% and the weight percentage of the B block is between 17% to 49.9%;
- and
- 2) a polyethylene glycol(PEG), a PEG derivative, or a mixtures of PEG and a PEG derivative, said PEG or PEG derivative having a molecular weight of 150 to 1100 Daltons;
- and
- wherein at least one of the biodegradable block copolymeric drug carriers is soluble in an aqueous solution and miscible with the PEG, PEG derivatives, or mixtures thereof, and wherein said composition can be reconstituted in water or an aqueous solution to form a homogeneous solution or an uniform colloidal system within 0.01 minutes to 180 minutes.
2 more elements
A composition comprising:
- 1) one or more biodegradable block copolymer drug carriers comprising A-B, A-B-A or B-A-B block copolymers having a total weight average molecular weight of 1000 to 100,000 Daltons, wherein the A block is a biodegradable polyester or poly(ortho ester) and the B block is polyethylene glycol(PEG), and the weight percentage of the A block is between 20% to 99% and the weight percentage of the B block is between 1% to 80%;
- and
- 2) a liquid polyethylene glycol(PEG), a PEG derivative, or a mixtures of PEG and a PEG derivative, said PEG or PEG derivative having a molecular weight of 150 to 1100 Daltons;
- wherein the biodegradable block copolymeric drug carrier is water insoluble but is soluble in the liquid PEG, a PEG derivative, or a mixtures of PEG and a PEG derivative.
1 more element
Dependencies are inferred from the claim text.