Bryostatin composition and bryostatin acquisition methodologies
AssigneeThe University of North Carolina at Chapel Hill
InventorsNiels Lindquist, Nicole Lopanik
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Abstract
Methods for obtaining bryostatins from the marine bryozoans of the Bugula neritina species complex are provided wherein the methods involve the extraction and purification of bryostatins from the larvae of Bugula neritina organisms. Further, the present invention relates to a novel bryostatin composition that may be extracted by Bugula neritina.
Claims17
A method of collecting bryostatins, comprising:
- subjecting Bugula neritina larvae to a condition sufficient to cause an exudate comprising bryostatin;
- and
- collecting the Bugula neritina larvae exudate.
A method of collecting bryostatins, comprising:
- collecting larvae of Bugula neritina;
- stressing the larvae;
- collecting an exudate from the stressed larvae;
- and
- isolating bryostatins from the larvae exudate.
A method of producing bryostatin, comprising:
- collecting larvae of Bugula neritina;
- and
- extracting bryostatin from said larvae.
A method of harvesting bryostatin from the larvae of Bugula neritina, comprising:
- collecting exudate from the larvae of Bugula neritina;
- and
- isolating bryostatin from the exudate.
A compound of the formula:
- 1
A bryostatin composition of the formula:
- 2
- obtained by a method comprising collecting exudate from the larvae of Bugula neritina.
Dependencies are inferred from the claim text.