Substituted C-cyclohexylmethylamine derivatives

A compound of formula I,

• 56
• wherein
• A is H;
• or singly or multiply substituted or unsubstituted aryl or heteroaryl;
• R1 is saturated or unsaturated, branched or unbranched, C1-10 alkyl or C3-10 cycloalkyl;
• aryl;
• heteroaryl;
• aryl bound by C1-3 alkyl or C1-3 alkylene or C1-3 ethinyl;
• C3-10 cycloalkyl bound by C1-3 alkyl or C1-3 alkylene or C1-3 ethinyl;
• or heteroaryl bound by C1-3 alkyl or C1-3 alkylene or C1-3 ethinyl, wherein R1 is unsubstituted, or singly or independently multiply substituted by:
• F, Cl, Br, I, OR18, SR18, SO2R18, SO2OR18, CN, COOR18, NR19R20;
• unsubstituted or singly or multiply substituted C1-10 alkyl, C3-10 cycloalkyl or silyl;
• unsubstituted or singly or multiply substituted aryl or heteroaryl;
• and unsubstituted or singly or multiply substituted aryl bound by saturated or unsaturated C1-3 alkyl, C1-3 alkylene, C3-10 cycloalkyl or heteroaryl;
• wherein
• R18 is H;
• saturated or unsaturated, branched or unbranched, unsubstituted or singly or multiply substituted C1-10 alkyl or C3-10 cycloalkyl;
• unsubstituted or singly or multiply substituted aryl or heteroaryl;
• or unsubstituted or singly or multiply substituted aryl, C3-10 cycloalkyl or heteroaryl bound by C1-3 alkyl, C1-3 alkylene;
• and
• R19 and R20 independently of one another are H;
• saturated or unsaturated, branched or unbranched, unsubstituted or singly or multiply substituted C1-10 alkyl or C3-10 cycloalkyl;
• unsubstituted or singly or multiply substituted aryl or heteroaryl;
• or unsubstituted or singly or multiply substituted aryl bound by C1-3 alkyl, C1-3 alkylene, C3-10 cycloalkyl or heteroaryl;
• or
• R19 and R20 together form CH2CH2OCH2CH2, CH2CH2NR21CH2CH2 or (CH2)3-6,
• wherein R21 is H;
• unsubstituted or substituted phenyl;
• or saturated or unsaturated, branched or unbranched, unsubstituted or singly or multiply substituted C1-10 alkyl;
• R2 and R3 independently of one another are H;
• saturated or unsaturated, branched or unbranched, singly or multiply substituted or unsubstituted C1-10 alkyl or C3-10 cycloalkyl;
• singly or multiply substituted or unsubstituted aryl or heteroaryl;
• or singly or multiply substituted or unsubstituted aryl bound by C1-3 alkyl, C1-3 alkylene, C3-10 cycloalkyl or heteroaryl;
• or
• R2 and R3 together represent CH2CH2OCH2CH2, CH2CH2NR6CH2CH2 or (CH2)3-6,
• wherein R6 is H;
• saturated or unsaturated, branched or unbranched, singly or multiply substituted or unsubstituted C1-10 alkyl or C3-10 cycloalkyl;
• singly or multiply substituted or unsubstituted aryl or heteroaryl;
• or singly or multiply substituted or unsubstituted aryl bound by C1-3 alkyl, C1-3 alkylene, C3-10 cycloalkyl or heteroaryl;
• X has such a meaning that partial formula Ia:
• 57
• partial formula Ia
• which is a part of formula I, is
• 58
• wherein B is OH, OR7, H, F, Cl or NR8R9,
• wherein R is saturated or unsaturated, branched or unbranched, singly or multiply substituted or unsubstituted C1-10 alkyl or C3-10 cycloalkyl;
• singly or multiply substituted or unsubstituted aryl or heteroaryl;
• or singly or multiply substituted or unsubstituted aryl bound by C1-3 alkyl, C1-3 alkylene, C3-10 cycloalkyl or heteroaryl;
• and
• R8 and R9 independently of one another are H;
• saturated or unsaturated, branched or unbranched, singly or multiply substituted or unsubstituted C1-10 alkyl or C3-10 cycloalkyl;
• singly or multiply substituted or unsubstituted aryl or heteroaryl;
• or singly or multiply substituted or unsubstituted aryl bound by C1-3 alkyl, C1-3 alkylene, C3-10 cycloalkyl or heteroaryl;
• or
• R8 and R9 together form CH2CH2OCH2CH2, CH2CH2NR10CH2CH2 or (CH2)3-6,
• wherein R10 is H;
• saturated or unsaturated, branched or unbranched, singly or multiply substituted or unsubstituted C1-10 alkyl or C3-10 cycloalkyl;
• singly or multiply substituted or unsubstituted aryl or heteroaryl;
• or singly or multiply substituted or unsubstituted aryl bound by C1-3 alkyl, C1-3 alkylene, C3-10 cycloalkyl or heteroaryl,
• and formula Ib,
• 59
• formula Ib
• which is also part of formula I, is
• 60
• wherein R4 is H, COR5, SO2R5;
• saturated or unsaturated, branched or unbranched, singly or multiply substituted or unsubstituted C1-10 alkyl or C3-10 cycloalkyl;
• singly or multiply substituted or unsubstituted aryl or heteroaryl;
• or singly or multiply substituted or unsubstituted aryl bound by C1-3 alkyl, C1-3 alkylene, C3-10 cycloalkyl or heteroaryl,
• wherein R5 is saturated or unsaturated, branched or unbranched, singly or multiply substituted or unsubstituted C1-10 alkyl or C3-10 cycloalkyl;
• singly or multiply substituted or unsubstituted aryl or heteroaryl;
• or singly or multiply substituted or unsubstituted aryl bound by C1-3 alkyl. C1-3 alkylene, C3-10 cycloalkyl or heteroaryl,
• wherein V is OR4 or NR4R11, and
• wherein W is R11, OR12 or NR11R12,
• wherein R11 and R12 independently of one another are H;
• saturated or unsaturated, branched or unbranched, singly or multiply substituted or unsubstituted C7-10 alkyl or C3-10 cycloalkyl;
• singly or multiply substituted or unsubstituted aryl or heteroaryl;
• or singly or multiply substituted or unsubstituted aryl bound by C1-3 alkyl, C1-3 alkylene, C3-10 cycloalkyl or heteroaryl,
• wherein the compound is in the form of a racemate, a pure stereoisomer, a mixture of stereoisomers in any mixing ratio, in the illustrated form or in the form of its acid, base or a salt, or in the form of a solvate,
• provided that the following compounds are excluded,
• in which
• A is hydrogen,
• R1 is a phenyl ring O- or S-substituted singly in the 3 position,
• R2 and R3 are both methyl,
• partial formula Ia is:
• 61
• wherein B is OH, and
• partial formula Ib is
• 62
• wherein R4 is C1-6 alkyl, C2-6 alkenyl, C5-7 cycloalkyl methyl, substituted or unsubstituted phenyl or substituted or unsubstituted benzyl, or in which
• R2, R3 independently of one another are H;
• branched or unbranched, singly or multiply substituted or unsubstituted, saturated or unsaturated C1-C10 alkyl;
• saturated or unsaturated, singly or multiply substituted or unsubstituted C3-C7 cycloalkyl or C3-C7 heterocycle in which a carbon atom is replaced by N, S or O in the ring;
• saturated or unsaturated, singly or multiply substituted or unsubstituted alkylaryl or alkylheteroaryl;
• or singly or multiply substituted or unsubstituted aryl or heteroaryl;
• or
• R2 and R3 together form a ring and represent CH2CH2OCH2CH2, CH2CH2NR6CH2CH2 or (CH2)3-6;
• partial formula Ia is
• 63
• wherein A is hydrogen,
• R1 is an unsubstituted or singly or doubly substituted phenyl ring,
• B is H, F, Cl, OH or OR7, wherein R7 is branched or unbranched, singly or multiply substituted or unsubstituted, saturated or unsaturated C1-C10 alkyl;
• singly or multiply substituted or unsubstituted saturated or unsaturated C3-C7 cycloalkyl or a C3-C7 heterocycle, in which a carbon atom is replaced in the ring by N, S or O;
• saturated or unsaturated, singly or multiply substituted or unsubstituted alkylaryl or alkylheteroaryl;
• or singly or multiply substituted or unsubstituted aryl or heteroaryl;
• and partial formula Ib is
• 64
• wherein V is OR4 wherein R4 is COR5 and wherein R5 is unsubstituted or singly or multiply substituted C1-6 alkyl.