Sulfonyl derivatives

A sulfonyl derivative represented by the following formula (I):

• 47
• [wherein R1 represents a hydrogen atom, a hydroxyl group, a nitro group, a cyano group, a halogen atom, an alkyl group, a hydroxyalkyl group, an alkoxyl group, an alkoxyalkyl group, a carboxyl group, a carboxyalkyl group, an alkylcarbonyl group, an alkoxycarbonyl group, an alkoxycarbonylalkyl group, an alkylcarbonyloxy group or a group A1-B1-(in which A1 represents an amino group which may have one or two substituents, a saturated or unsaturated 5- or 6-membered cyclic hydrocarbon group which may have a substituent or a saturated or unsaturated 5- or 6-membered heterocyclic group which may have a substituent and B1 represents a single bond, a carbonyl group, an alkylene group, a carbonylalkyl group, a carbonylalkyloxy group or an alkylenecarbonyloxy group),
• R2 and R3 each independently represents a hydrogen atom, a halogen atom, an alkyl group, a hydroxyalkyl group or an alkoxyalkyl group or R2 or R3 may be coupled together with R1 to form a C1-3 alkylene or alkenylene group,
• R4 and R5 each independently represents a hydrogen atom, a hydroxyl group, a halogen atom, an alkyl group or an alkoxyl group (with the proviso that R4 and R5 do not represent a hydrogen atom at the same time),
• Q1 represents a saturated or unsaturated 5- or 6-membered cyclic hydrocarbon group which may have a substituent, a saturated or unsaturated 5- or 6-membered heterocyclic group which may have a substituent or a saturated or unsaturated bicyclic or tricyclic fused ring group which may have a substituent,
• Q2 represents a single bond, an oxygen atom, a sulfur atom, a linear or branched C1-6 alkylene group, a linear or branched C2-6 alkenylene group, a linear or branched C2-6 alkynylene group, a group —N(R6)—CO— (in which R6 represents a hydrogen atom or an alkyl group), a group —N(R7)—(CH2)m- (in which R7 represents a hydrogen atom or an alkyl group and m stands for an integer of 0 to 6) or a group of the following formula:
• 48
• (which represents a divalent, saturated or unsaturated 5- or 6-membered cyclic hydrocarbon group which may have a substituent, a divalent saturated or unsaturated 5- or 6-membered heterocyclic group which may have a substituent or a divalent saturated or unsaturated dicyclic fused ring group which may have a substituent and ←C means the bonding of the carbon atom of this group to Q1),
• Q3 represents any one of the following groups:
• 49
• (in which when the carbon atom to which each of R8, R9, R10, R11, R12, R13, R15 and R16 is bonded is not adjacent to a nitrogen atom, R8, R9, R10, R11, R12, R13, R15 and R16 each independently represents:
• a hydrogen atom,
• a hydroxyl group,
• an alkyl group,
• an alkoxyl group,
• an alkoxyalkyl group,
• an alkoxyalkyloxy group,
• a hyroxyalkyl group,
• a hydroxyalkyloxy group,
• a hydroxyalkylsulfonyl group,
• a formyl group,
• a formylalkyl group,
• a formylalkylcarbonyl group,
• a formylalkylsulfonyl group,
• an alkylcarbonyl group,
• an alkylsulfonyl group,
• an alkylcarbonylalkyl group,
• an alkylsulfonylalkyl group,
• a carboxyl group,
• a carboxyalkyl group,
• a carboxyalkyloxy group,
• a carboxyalkylcarbonyl group,
• a carboxyalkylsulfonyl group,
• a carboxyalkylcarbonylalkyl group,
• a carboxyalkylsulfonylalkyl group,
• an alkoxycarbonyl group,
• an alkoxycarbonylalkyl group,
• an alkoxycarbonylalkyloxy group,
• an alkoxycarbonylalkylcarbonyl group,
• an alkoxycarbonylalkylsulfonyl group,
• an amino group which may have one or two substituents, an aminoalkyl group in which the amino moiety may have one or two substituents,
• an aminoalkyloxy group in which the amino moiety may have one or two substituents,
• an aminoalkylcarbonyl group in which the amino moiety may have one or two substituents,
• an aminoalkylcarbonyloxy group in which the amino moiety may have one or two substituents,
• an aminocarbonyl group in which the amino moiety may have one or two substituents,
• an aminocarbonylalkyl group in which the amino moiety may have one or two substituents,
• an aminocarbonylalkyloxy group in which the amino moiety may have one or two substituents or
• a group A2-B2- (in which A2 represents a saturated or unsaturated 5- or 6-membered cyclic hydrocarbon group which may have a substituent or a saturated or unsaturated 5- or 6-membered heterocyclic group which may have a substituent and B2 represents a single bond, a carbonyl group or an alkylene group),
• when the carbon atom to which each of R8, R9, R10, R11, R12, R13, R15 and R16 is bonded is adjacent to a nitrogen atom, R8, R9, R10, R11, R12, R13, R15 and R16 each independently represents:
• a hydrogen atom,
• an alkyl group,
• a hyroxyalkyl group,
• a hyroxyalkylcarbonyl group,
• a hydroxyalkylsulfonyl group,
• a formyl group,
• a formylalkyl group,
• a formylalkylcarbonyl group,
• a formylalkylsulfonyl group,
• an alkylcarbonyl group,
• an alkylsulfonyl group,
• an alkylcarbonylalkyl group,
• an alkylsulfonylalkyl group,
• a carboxyl group,
• a carboxyalkyl group,
• a carboxyalkylcarbonyl group,
• a carboxyalkylsulfonyl group,
• a carboxyalkylcarbonylalkyl group,
• a carboxyalkylsulfonylalkyl group,
• an alkoxyalkyl group,
• an alkoxycarbonyl group,
• an alkoxycarbonylalkyl group,
• an alkoxycarbonylalkylcarbonyl group,
• an alkoxycarbonylalkylsulfonyl group,
• an aminoalkyl group in which the amino moiety may have one or two substituents,
• an aminoalkylcarbonyl group in which the amino moiety may have one or two substituents,
• an aminocarbonyl group in which the amino moiety may have one or two substituents,
• an aminocarbonylalkyl group in which the amino moiety may have one or two substituents or
• a group A3-B3 - (in which A3 represents a saturated or unsaturated 5- or 6-membered cyclic hydrocarbon group which may have a substituent or a saturated or unsaturated 5- or 6-membered heterocyclic group which may have a substituent and B3 represents a single bond, a carbonyl group or an alkylene group),
• R8 and R9, R10 and R11, R12 and R13, and R15 and R16 may each be coupled together with a carbon atom which constitutes the ring and represent a saturated or unsaturated 5- to 7-membered cyclic hydrocarbon group which may have a substituent or a saturated or unsaturated 5- to 7-membered heterocyclic group which may have a substituent,
• R14 and R17 each independently represents:
• a hydrogen atom,
• an alkyl group,
• a hydroxyalkyl group,
• a hyroxyalkylcarbonyl group,
• a hydroxyalkylsulfonyl group,
• an alkoxyl group,
• an alkoxyalkyl group,
• an alkoxyalkylcarbonyl group,
• an alkoxyalkylsulfonyl group,
• a formyl group,
• a formylalkyl group,
• a formylalkylcarbonyl group,
• a formylalkylsulfonyl group,
• an alkylcarbonyl group,
• an alkylcarbonylalkyl group,
• an alkylsulfonyl group,
• an alkylsulfonylalkyl group,
• a carboxyalkyl group,
• a carboxyalkylcarbonyl group,
• a carboxyalkylsulfonyl group,
• a carboxyalkylcarbonylalkyl group,
• a carboxyalkylsulfonylalkyl group,
• an alkoxycarbonyl group,
• an alkoxycarbonylalkyl group,
• an alkoxycarbonylalkylcarbonyl group,
• an alkoxycarbonylalkylsulfonyl group,
• an amino group which may have one or two substituents,
• an aminoalkyl group in which the amino moiety may have one or two substituents,
• an aminoalkyloxy group in which the amino moiety may have one or two substituents,
• an aminoalkylcarbonyl group in which the amino moiety may have one or two substituents,
• an aminoalkyloxycarbonyl group in which the amino moiety may have one or two substituents,
• an aminocarbonyl group in which the amino moiety may have one or two substituents,
• an aminocarbonylalkyl group in which the amino moiety may have one or two substituents, and
• an aminocarbonyloxyalkyl group in which the amino moiety may have one or two substituents,
• R14 and R12 or R13 may be coupled together with a carbon atom constituting a ring and with a nitrogen atom to which R14 is bonded to form a saturated or unsaturated 5- to 7-membered heterocyclic group which may have a substituent,
• R17 and R15 or R16 may be coupled together with a carbon atom constituting a ring and with a nitrogen atom to which R17 is bonded to form a saturated or unsaturated 5- to 7-membered heterocyclic group which may have a substituent, and
• a, b, d, e and g each independently stands for an integer of 0 or 1, c stands for an integer of 0 to 3, f, h and i each independently represents an integer of 1 to 3, with the proviso that the sum of a, b and c stands for an integer of 2 or 3, the sum of d and e stands for an integer of 0 or 1 and the sum of f, g and h stands for an integer of 3 to 5),
• T1 represents a carbonyl group,
• a group —CH(R18)— (in which R18 represents a hydrogen atom, an alkyl group, a hydroxyalkyl group, an alkoxyalkyl group, a carboxyalkyl group, an alkoxycarbonylalkyl group, an aryl group, an aralkyl group, a heteroaryl group, a heteroarylalkyl group or an aminoalkyl group in which the amino moiety may have a substituent) or
• a group −C(═NOR19)— (in which R19 represents a hydrogen atom, an alkyl group, a carboxyalkyl group, an alkoxycarbonyl group, an aryl group, an aralkyl group, a heteroaryl group, a heteroarylalkyl group or an aminoalkyl group in which the amino moiety may have a substituent),
• X1 and X2 each independently represents a methine group or a nitrogen atom];
• salt thereof;
• or solvate thereof.