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US 2003/0232008 A1Published application
Oxazolidinone photoaffinity probes
AssigneePharmacia & Upjohn Company
InventorsLisa Marie Thomasco, Robert C. Gadwood
Life of this patent
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Abstract
Disclosed are novel compounds that are useful and effective as photoaffinity probes and methods of using oxazolidinone photoaffinity probes.
Claims26
A compound comprising the formula
- 49
- wherein:
- X and Y are, independently, F, H or CH3;
- R1 is H or I;
- R2 is H or OH;
- R3 is H or C1-C8 alkyl;
- L is a bond or —OCH2C(═O);
- and
- Q is
- 50
- wherein:
- R4 is H, CH3, CH2CH3 or cyclopropyl;
- and
- Z is O or S;
- or a pharmaceutically acceptable salt thereof.
12 more elements
A compound comprising the formula
- 51
- wherein:
- X and Y are, independently, F, H or CH3;
- R1 is H or I;
- R2 is H or OH;
- and
- Q is
- 52
- wherein:
- R4 is H, CH3, CH2CH3 or cyclopropyl;
- and
- Z is O or S;
- or a pharmaceutically acceptable salt thereof.
10 more elements
A compound comprising the formula
- 53
- wherein:
- X and Y are, independently, F, H or CH3;
- R5 is
- 54
- wherein:
- R6 is H, N3, halogen, NH2, OH, SH, C1-C4 alkylamino, C1-C4 dialkylamino, C1-C4 alkyl, nitrile, carboxamide, C1-C4 alkoxy, C1-C4 alkylthio, or C1-C4 alkoxycarbonyl;
- and
- P is
- 55
- wherein:
- Z is O or S;
- and
- R7 is
- 56
- wherein:
- R1 is H or I;
- and
- R2 is H or OH;
- or a pharmaceutically acceptable salt thereof.
17 more elements
A method of using a compound comprising the formula
- 57
- wherein:
- X and Y are, independently, F, H or CH3;
- R8 is H or I;
- R9 is H or OH;
- R11 is H or C1-C8 alkyl;
- L is a bond or —OCH2C(═O);
- and
- Q is
- 58
- wherein:
- R11 is H, CH3, CH2CH3 or cyclopropyl;
- and
- Z is O or S;
- or a pharmaceutically acceptable salt thereof, as a photoaffinity probe.
12 more elements
A method of using a compound comprising the formula
- 59
- wherein:
- X and Y are, independently, F, H or CH3;
- R12 is N3 or
- 60
- wherein:
- R8 is H or I;
- and
- R9 is H or OH;
- and
- Q is
- 61
- wherein:
- R11 is H, CH3, CH2CH3 or cyclopropyl;
- and
- Z is O or S;
- or a pharmaceutically acceptable salt thereof, as a photoaffinity probe.
14 more elements
A method of using a compound comprising the formula
- 62
- wherein:
- X and Y are, independently, F, H or CH3;
- R13 is
- 63
- wherein:
- R14 is H, N3, halogen, NH2, OH, SH, C1-C4 alkylamino, C1-C4 dialkylamino, C1-C4alkyl, nitrile, carboxamide, C1-C4 alkoxy, C1-C4 alkylthio, or C1-C4 alkoxycarbonyl;
- and
- P is
- 64
- wherein:
- Z is O or S;
- and
- R15 is
- 65
- wherein:
- R8 is H or I;
- and
- R9 is H or OH;
- or a pharmaceutically acceptable salt thereof, as a photoaffinity probe.
17 more elements
Dependencies are inferred from the claim text.