Phosphoribosylaminoimidazole carboxylase
OwnerStephen M. Allen, Emil M. Orozco JR. +1inventors
InventorsStephen M. Allen, Emil M. Orozco JR., Jian-Ming Lee
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Abstract
This invention relates to an isolated nucleic acid fragment encoding a phosphoribosylaminoimidazole carboxylase. The invention also relates to the construction of a recombinant DNA construct or chimeric gene encoding all or a portion of the phosphoribosylaminoimidazole carboxylase, in sense or antisense orientation, wherein expression of the recombinant DNA construct or chimeric gene results in production of altered levels of the phosphoribosylaminoimidazole carboxylase in a transformed host cell.
Claims21
An isolated polynucleotide comprising:
- (a) a nucleotide sequence encoding a polypeptide having phosphoribosylaminoimidazole carboxylase activity, wherein the polypeptide has an amino acid sequence of at least 80% sequence identity, based on the Clustal V method of alignment, when compared to one of SEQ ID NO:2, 4, 6, 8 or 17, or
- (b) a complement of the nucleotide sequence, wherein the complement and the nucleotide sequence consist of the same number of nucleotides and are 100% complementary.
An isolated polypeptide having phosphoribosylaminoimidazole carboxylase activity, wherein the polypeptide has an amino acid sequence of at least 80% sequence identity, based on the Clustal V method of alignment, when compared to one of SEQ ID NO:2, 4, 6, 8 or 17.
Dependencies are inferred from the claim text.