Ultrasound therapy
AssigneeGendel Limited
InventorsRoger Kingdon Craig, Anthony Patrick McHale, Ana Maria Rollan-Haro
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Abstract
Described and claimed is the combined use of an electric field and ultrasound to ablate a cell or tissue, the use of ultrasound to disrupt a nucleated cell which has previously been electrosensitised by exposure to an electric field, and the use of an electric field for sensitising a nucleated cell to ultrasound. We furthermore disclose the use of electricity to disrupt a nucleated cell which has previously been sensitised by exposure to ultrasound, and the use of ultrasound for sensitising a nucleated cell to electricity.
Claims38
A method of using an electric field and ultrasound to ablate a cell or tissue, wherein the cell or tissue is optionally part of a tissue mass.
A method of using an electric field to sensitise a nucleated cell to ultrasound.
A method of using ultrasound to sensitise a nucleated cell to electricity.
A method of inducing apoptosis in a cell, the method comprising exposing the cell to an electric field, and exposing the cell to ultrasound.
A method of identifying a gene product which is involved in an apoptotic process or in modulating such a process.
A method of identifying a molecule which is capable of modulating apoptosis of a cell, the method comprising the steps of:
- (a) contacting a cell with a candidate molecule;
- (b) exposing the cell to an electric field;
- (c) exposing the cell to ultrasound;
- and
- (d) determining whether apoptosis is modulated as a result of the contacting.
Dependencies are inferred from the claim text.