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US 2003/0229227 A1Published application
New difurylglycolic acid esters, processes for the preparation thereof as well as the use thereof as pharmaceutical compositions
AssigneeBoehringer Ingelheim Pharma GmbH & Co. KG
InventorsGerd Morschhaeuser, Michael P. Pieper, Georg Speck
Life of this patent
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Abstract
Difurylglycolic acid esters of the formula 1 1 wherein X− and the groups A, R, R1, R2, R3 and R3′ may have the meanings given in the claims and in the specification, processes for preparing them and their use for treating asthma, COPD, vagally induced sinus bradycardia, heart rhythm disorders, spasms in the gastrointestinal tract, spasms in the urinary tract or menstrual pain.
Claims12
A compound of the formula 1
- 16
- wherein
- A denotes a double-bonded group selected from the group consisting of
- 17
- X− denotes an anion with a single negative charge;
- R denotes hydrogen, hydroxy, methyl, ethyl, —CF3, CHF2 or fluorine;
- R1 and R2 which may be identical or different denote —C1-C5-alkyl, which may optionally be substituted by —C3-C6-cycloalkyl, hydroxy or halogen, or
- R1 and R2 together denote a —C3-C5-alkylene bridge;
- and,
- R3 and R3′ which may be identical or different denote furyl which may optionally be mono-, di- or trisubstituted by a group selected from the group consisting of —C1-C4-alkyl, —C1-C4-alkyloxy, hydroxy, —CF3, —CHF2, CN, NO2 and halogen.
7 more elements
A compound of the formula 4
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- wherein:
- A denotes a double-bonded group selected from the group consisting of
- 22
- R denotes hydrogen, hydroxy, methyl, ethyl, —CF3, CHF2 or fluorine;
- R1 denotes —C1-C5-alkyl, which may optionally be substituted by —C3-C6-cycloalkyl, hydroxy or halogen;
- and,
- R3 and R3′ which may be identical or different denote furyl which may optionally be mono-, di- or trisubstituted by a group selected from the group consisting of —C1-C4-alkyl, —C1-C4-alkyloxy, hydroxy, —CF3, —CHF2, CN, NO2 and halogen;
- or an acid addition salt thereof.
6 more elements
Dependencies are inferred from the claim text.