Cyclopentenone derivatives for cancer therapy

A compound of the formula 1

• 13
• derivatives or salts thereof, wherein X is oxygen, hydroxyimino, alkoxyimino, aryloxyimino or arylimino;
• R is hydroxy, oxo, amino, alkylamino, hydroxyimino, alkoxyimino, aryloxyimino alkylcarbonyloxy, aroyloxy, alkoxy, methoxymethyloxy, 2-methoxyethoxymethyloxy, tert-butyldimethylsilyloxy, trimethylsilyloxy, carboxyl acid, carboxylate salt, or carboxylic acid ester;
• R1 to R10 are the same or different and represent hydrogen, hydroxy, alkyl, alkoxy, methoxymethyloxy, 2-methoxyethoxymethyloxy, tert-butyldimethylsilyloxy, trimethylsilyloxy, chloro, fluoro, bromo, mercapto, alkylthio, nitro, amino, monoalkylamino, dialkylamino, azido, carboxyl, carbalkoxy, alkylcarbonyloxy, carboxymethyloxy, NHCOCH3, NHCOCF3, NH-alkyl, NH-dialkyl, CN, guanidine, NHCOOR11, CH2C═NR12NR13;
• NHNH2, NHCONH2, NHNHCONH2, NHNHC(═S)NH2 and their salts;
• OPO3H2, OPO3Na2, OPO3K2, SO2NH2, CONH-alkyl (preferably C1-C4), CHO, CH═NOH, or —(CH2—CH2—N[CH3])— fused at R8, R9 positions respectively, or methylenedioxy group fused in lieu of either R8, R9 or R9, R10 position, respectively, and in the latter R8 is alkoxy and R11, R12, and R13, are selected from C1-C4 alkyl groups