Heteroaromatic substituted cyclopropane as corticotropin releasing hormone ligands

A compound of Formula (I):

• 31
• or a pharmaceutically acceptable salt form thereof, wherein:
• W is CR6, NR6,
• 32
• X is C or N;
• Y is CR1 or N;
• Z is C or N;
• R1 is H, halogen, aryl, heteroaryl, heterocyclyl, C1-C6 alkyl, C1-C6 haloalkyl, C2-C6 alkenyl, C2-C6 alkynyl, —CN, —CH2CN, —CH2OR13, CH2NR13R14, —CH2OH, —NO2, C3-C6 cycloalkyl, —NR13R14, —NR13COR14, —NHSO2R, —COR13, —CO2R13, —OR13, —OC2H4OR13, —SR13, —S(O)nR13, —S(O)nNR13R14, —CH(OH)R13, —CH2COR13, —OC(O)R13, —OCHR13CO2R14, —OCHR13COR14, —NR13CONR13R14, —NR13CO2R4, —CONR13R14, or —CH(OH)C(R13)3;
• R2 is H, halogen, aryl, heteroaryl, heterocyclyl, C1-C6 alkyl, C1-C6 haloalkyl, C2-C6 alkenyl, C2-C6 alkynyl, —CN, —CH2CN, —CH2OR15, CH2NR15R16, —CH2OH, —NO2, C3-C6 cycloalkyl, —NR15R16, —NR15COR16, —NHSO2R, —COR15, —CO2R15, —OR15, —OC2H4OR15, —SR15, —S(O)nR15, —S(O)nNR15R16, —CH(OH)R15, —CH2COR15, —OC(O)R15, —OCHR15CO2R16, —OCHR15COR16, —NR15CONR15R16, —NR15CO2R16, —CONR15R16, or —CH(OH)C(R15)3;
• R3 is H, halogen, aryl, heteroaryl, heterocyclyl, C1-C6 alkyl, C1-C6 haloalkyl, C2-C6 alkenyl, C2-C6 alkynyl, —CN, —CH2CN, —CH2OR17, CH2NR17R18, —CH2OH, —NO2, C3-C6 cycloalkyl, —NR17R18, —NR17COR18, —NHSO2R, —COR17, —CO2R17, —OR17, —OC2H4OR17, —SR17, —S(O)nR17, —S(O)nNR17R18, —CH(OH)R17, —CH2COR17, —OC(O)R17, —OCHR17CO2R18, —OCHR17COR18, —NR17CONR17R18, —NR17CO2R18, —CONR17R18, or —CH(OH)C(R17)3;
• each R4 and R5 is, independently, H, halogen, aryl, heteroaryl, heterocyclyl, C1-C6 alkyl, C1-C6 haloalkyl, C2-C6 alkenyl, C2-C6 alkynyl, —CN, —CH2CN, —CH2OR19, CH2NR19R20, —CH2OH, —NO2, C3-C6 cycloalkyl, —NR19R20, —NR19COR20, —NHSO2R, —COR19, —CO2R19, —OR19, —OC2H4OR19, —SR19, —S(O)nR19, —S(O)nNR19R20, —CH(OH)R19, —CH2COR19, —OC(O)R19, —OCHR19CO2R20, —OCHR19COR20, —NR19CONR19R20, —NR19CO2R20, —CONR19R20, or —CH(OH)C(R19)3;
• R6 is H, halogen, aryl, heteroaryl, heterocyclyl, C1-C6 alkyl, C1-C6 haloalkyl, C2-C6 alkenyl, C2-C6 alkynyl, —CN, —CH2CN, —CH2OR21, CH2NR21R22, —CH2OH, —NO2, C3-C6 cycloalkyl, —NR21R22, —NR21COR22, —NHSO2R, —COR21, —CO2R21, —OR21, —OC2H4OR21, —SR21, —S(O)nR21, —S(O)nNR21R22, —CH(OH)R21, —CH2COR21, —OC(O)R21, —OCHR21CO2R22, —OCHR21COR22, —NR21CONR21R22, —NR21CO2R22, —CONR21R22, or —CH(OH)C(R21)3;
• each R7, R8 and R9 is, independently, H, halogen, aryl, heteroaryl, heterocyclyl, C1-C6 alkyl, C1-C6 haloalkyl, C2-C6 alkenyl, C2-C6 alkynyl, —CN, —CH2CN, —CH2OR23, CH2NR23R24, —CH2OH, —NO2, C3-C6 cycloalkyl, —NR23R24, —NR23COR24, —NHSO2R, —COR23, —CO2R23, —OR23, —OC2H4OR23, —SR23, —S(O)nR23, —S(O)nNR23R24, —CH(OH)R23, —CH2COR23, —OC(O)R23, —OCHR23CO2R24, —OCHR23COR24, —NR23CONR23R24, —NR23CO2R24, —CONR23R24, or —CH(OH)C(R23)3;
• each R10 is, independently, H, halogen, C1-C6 alkyl, C1-C6 haloalkyl, C3-C6 cycloalkyl, C2-C6 alkenyl, C2-C6 alkynyl, C1-C6 alkoxy, C1-C6 haloalkoxy, aryl, heteroaryl or heterocyclyl, —CN, —CH2CN, —CH2OR23, CH2NR23R24, —CH2OH, —NO2, C3-C6 cycloalkyl, —NR23R24, —NR23COR24, —NHSO2R, —COR23, —CO2R23, —OR24, —OC2H4OR23, —SR23, —S(O)nR23, —S(O)nNR23R24, —CH(OH)R23, —CH2COR23, —OC(O)R23, —OCHR23CO2R24, —OCHR23COR24, —NR23CONR23R24, —NR23CO2R24, —CONR23R24, or —CH(OH)C(R23)3, wherein each alkyl, haloalkyl, or cycloalkyl is optionally substituted with one or more groups independently selected from halogen, hydroxyl, or —CN;
• each R11 and R12 is, independently, H, —NH2, C1-C6 alkyl, C1-C6 haloalkyl, C3-C6 cycloalkyl, aryl, heteroaryl or heterocyclyl, where each alkyl, haloalkyl, or cycloalkyl is optionally substituted with one or more groups independently selected from halogen, hydroxyl, or —CN;
• each R13 and R14 is, independently, H, —NH2, C1-C6 alkyl, C1-C6 haloalkyl, C3-C6 cycloalkyl, aryl, heteroaryl or heterocyclyl, where each alkyl, haloalkyl, or cycloalkyl is optionally substituted with one or more groups independently selected from halogen, hydroxyl, or —CN;
• each R15 and R16 is, independently, H, —NH2, C1-C6 alkyl, C1-C6 haloalkyl, C3-C6 cycloalkyl, aryl, heteroaryl or heterocyclyl, where each alkyl, haloalkyl, or cycloalkyl is optionally substituted with one or more groups independently selected from halogen, hydroxyl, or —CN;
• each R17 and R18 is, independently, H, —NH2, C1-C6 alkyl, or haloalkyl, C3-C6 cycloalkyl, aryl, heteroaryl or heterocyclyl, where each alkyl, haloalkyl, or cycloalkyl is optionally substituted with one or more groups independently selected from halogen, hydroxyl, or —CN;
• each R19 and R20 is, independently, H, —NH2, C1-C6 alkyl, C1-C6 haloalkyl, C3-C6 cycloalkyl, aryl, heteroaryl or heterocyclyl, where each alkyl, haloalkyl, or cycloalkyl is optionally substituted with one or more groups independently selected from halogen, hydroxyl, or —CN;
• each R21 and R22 is, independently, H, —NH2, C1-C6 alkyl, C1-C6 haloalkyl, C3-C6 cycloalkyl, aryl, heteroaryl or heterocyclyl, where each alkyl, haloalkyl, or cycloalkyl is optionally substituted with one or more groups independently selected from halogen, hydroxyl, or —CN;
• each R23 and R24 is, independently, H, —NH2, C1-C6 alkyl, C1-C6 haloalkyl, C3-C6 cycloalkyl, aryl, heteroaryl or heterocyclyl, where each alkyl, haloalkyl, or cycloalkyl is optionally substituted with one or more groups independently selected from halogen, hydroxyl, or —CN;
• alkyl, C1-C6 haloalkyl, C2-C6 alkenyl, C2-C6 alkynyl, —CN, —NO2, —CH2OH, C3-C6 cycloalkyl, —NR11R12, —NR11COR12, —COR11, —CO2R11, —OR11, —SR11, —S(O)nR11, —CH(OH)R11, —CH2COR11, —OC(O)R11, —NR11CONR11R12, —NR11CO2R12, —CONR11R12, and —CH(OH)C(R11)3;
• and
• heterocyclyl is optionally substituted with 1 to 10 substituents independently selected at each occurrence from H, halogen, C1-C6 alkyl, C1-C6 haloalkyl, C2-C6 alkenyl, C2-C6 alkynyl, —CN, —NO2, —CH2OH, C3-C6 cycloalkyl, —NR11R12, —NR11COR12, —COR11, —CO2R11, —OR11, —SR11, —S(O)nR11, —CH(OH)R11, —CH2COR11, —OC(O)R11, —NR11CONR11R12, —NR11CO2R12, —CONR11R12, and —CH(OH)C(R11)3.