Compounds and their use in medicine, process for their preparation and pharmaceutical compositions containing them

A compound of the formula (I)

• 124
• its derivatives, its analogs, its tautomeric forms, its stereoisomers, its polymorphs, its pharmaceutically acceptable salts, their pharmaceutically acceptable solvates, wherein:
• R1 represents hydrogen, hydroxy, halogen, linear or branched (C1-C12) alkyl, linear or branched (C1-C12) alkoxy, substituted or unsubstituted arylalkyl group or forms a bond together with the adjacent group R2;
• R2 represents hydrogen, halogen, linear or branched (C1-C12) alkyl, linear or branched (C1-C12) alkoxy, (C1-C12) alkanoyl, aroyl, arylalkanoyl, substituted or unsubstituted arylalkyl or R2 forms a bond together with R1;
• R3 represents hydrogen atom or substituted or unsubstituted groups selected from linear or branched (C1-C12)alkyl, cycloalkyl, cycloalkylalkyl, cycloalkenyl, aryl, (C1-C12)alkanoyl, aroyl, arylalkyl, arylalkanoyl, heterocyclyl, heteroaryl, heteroarylalkyl, alkoxyalkyl, alkoxycarbonyl, aryloxycarbonyl, alkylaminocarbonyl, or arylaminocarbonyl groups;
• R4 represents hydrogen or substituted or unsubstituted groups selected from linear or branched (C1-C12) alkyl, cycloalkyl, aryl, arylalkyl, heterocyclyl, heteroaryl or heteroarylalkyl groups;
• Y represents oxygen, NR7 or N(R7)O, where R7 represents hydrogen or substituted or unsubstituted groups selected from (C1-C12) alkyl, aryl, arylalkyl, hydroxyalkyl, alkanoyl, aroyl, arylalkanoyl, heterocyclyl, heteroaryl, heteroarylalkyl, alkoxycarbonyl or arylalkoxycarbonyl groups;
• or R4 and R7 together form a substituted or unsubstituted 5 or 6 membered cyclic structure containing carbon atoms and a nitrogen atom, which may optionally contain one or more additional heteroatoms selected from oxygen, sulfur or nitrogen;
• R5 represents hydrogen or substituted unsubstituted group selected from alkyl, alkenyl, cycloalkyl, cycloalkylalkyl, aryl or arylalkyl group;
• Ar represents substituted or unsubstituted groups selected from divalent phenylene, naphthylene, pyridyl, quinolinyl, benzofuryl, dihydrobenzofuryl, benzopyranyl, dihydrobenzopyranyl, indolyl, indolinyl, azaindolyl, azaindolinyl, pyrazolyl, benzothiazolyl, or benzoxazolyl;
• X represents —C(═O)—, —C(═S)—, —C(═S)—O, —C(═O)—O—, —C(═O)—S—, —C(═S)—O—, —O—(CH2)d-, —NH—(CH2)d— where d is 1 to 4, —O—C(═O)—, —C(O)CH2—, —CRa═CRb—CH2—;
• —CRa=CRb—CO— where Ra and Rb are the same or different and represent hydrogen or (C1-C6)alkyl or X represents a bond;
• R6 represents substituted or unsubstituted group selected from aryloxycarbonyl, arylalkoxycarbonyl, alkylcarbonyloxy, alkoxycarbonylamino, aryloxycarbonylamino, arylalkoxycarbonylamino, fluorenylmethoxycarbonyl (Fmoc), fluorenylmethoxycarbonylamino (N-Fmoc), —OSO2R8, —OCONR8R9, NR8COOR9, —NR8COR9, —NR8SO2R9, NR8CONR9R0, —NR8CSNR8R9, —SO2R8, —SOR8, —SR8, —SO2NR8R9, —SO2OR8, —COOR9, —COR9 or —CONR8R9, wherein R8, R9 and R10 are the same or different and independently represent hydrogen, or substituted or unsubstituted alkyl, aryl, arylalkyl, alkoxycarbonyl or arylalkoxycarbonyl;
• R8 and R9 when present on nitrogen atom together form a 5 or 6 membered cyclic structure containing carbon atoms and one or more heteroatoms selected from oxygen, sulfur or nitrogen;
• or R6 is hydrogen, when R13 is at the third position of the phenyl ring and does not represent hydrogen;
• R13 represents hydrogen, halogen, nitro, cyano, amino, haloalkyl, hydroxy or substituted or unsubstituted group selected from linear or branched (C1-C12)alkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, heterocyclyl, alkoxy, monoalkylamino, dialkylamino, alkoxycarbonyl, aryloxycarbonyl, arylalkoxycarbonyl, aryloxy, arylalkoxy, alkylcarbonyloxy, alkoxycarbonylamino, aryloxycarbonylamino, arylalkoxycarbonylamino, fluorenylmethoxycarbonyl (Fmoc), fluorenylmethoxycarbonylamino (N-Fmoc), —OSO2R8, —OCONR8R9, NR8COOR9, —NR8COR9, —NR8R9, —NR8SO2R9, NR8CONR9R10, —NR8CSNR8R9, —SO2R8, —SOR8, —SR8, —SO2NR8R9, —SO2OR8, —COOR9, —COR9, —CONR8R9, wherein R8, R9 and R10 are the same or different and independently represent hydrogen, or substituted or unsubstituted alkyl, aryl, arylalkyl, alkoxycarbonyl or arylalkoxycarbonyl;
• R8 and R9 when present on nitrogen atom together form a 5 or 6 membered cyclic structure containing carbon atoms and one or more heteroatoms selected from oxygen, sulfur or nitrogen;
• n is 1 to 6, and m is 0 to 6.