Indole derivatives as pde5-inhibitors

A compound having a formula

• 26
• wherein R0, independently, is selected from the group consisting of halo and C1-6alkyl;
• R1 is selected from the group consisting of hydrogen, C1-6alkyl, C2-6alkenyl, C0-6alkynyl, haloC1-6-alkyl, C3-8cycloalkyl, C3-8cycloalkylC1-3alkyl, aryl-C1-3alkyl, and heteroarylC1-3alkyl;
• R2 is selected from the group consisting of an optionally substituted monocyclic aromatic ring selected from the group consisting of benzene, thiophene, furan, and pyridine, and an optionally substituted bicyclic ring
• 27
• wherein the fused ring A is a 5- or 6-membered ring, saturated or partially or fully unsaturated, and comprises carbon atoms and optionally one or two heteroatoms selected from oxygen, sulfur, and nitrogen;
• R3 is selected from the group consisting of hydrogen and C1-3alkyl,
• or R1 and R3 together represent a 3- or 4-membered alkyl or alkenyl chain component of a 5- or 6-membered ring;
• X and Y, independently, are selected from the group consisting of C(═O), SO, SO2, C(═S), and C(Ra)21 and with the proviso that at least one of X and Y is different from C(═O);
• Ra is hydrogen, C1-6alkyl, or benzyl;
• and q is 0, 1, 2, 3, or 4,
• and pharmaceutically acceptable salts and solvates thereof.