US 2003/0228666 A1Published application

Novel human thrombopoietin mutein

AssigneeDaewoong Pharmaceutical Co., Ltd.

InventorsJoo Young Chung, Sang Kyu Park, Sang Myoung Ju, Hyea Kyung Ahn, Seung Wook Lim, Woo Ik Chang, Seung Kook Park, Yeo Wook Koh, Ji Soo Park

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Abstract

The present invention relates to novel human thrombopoietin (; hTPO) derivatives, and to process of preparation thereof. Particularly, sugar chains are introduced into native hTPO by substituting amino acids such as asparagine for amino acids at specific positions in native hTPO, preparing novel hTPO derivatives with high activities enhancing the platelet production in vivo. Therefore, the novel hTPO derivatives of this invention may be useful for the treatment of thrombocytopenia associated with anticancer therapy or the transplantation of bone marrow.

Claims12

Dependent claims

Human thrombopoietin derivative which derived from human thrombopoietin (hTPO) described by SEQ ID NO:

30;
which has at least one additional N-linked glycosylation site;
and which is selected from the group comprising:
[Asn108] hTPO;
[Asn117] hTPO;
[Asn147] hTPO;
[Asn153] hTPO;
[Asn164] hTPO;
[Asn193] hTPO;
[Asn117, Asn147] hTPO;
[Asn117, Asn164] hTPO;
[Asn108, Asn147] hTPO;
[Asn108, Asn164] hTPO;
[Asn147, Asn164] hTPO;
[Asn117, Asn147, Asn164] hTPO;
[Asn108, Asn147, Asn164] hTPO;
[Asn108, Asn117, Asn164] hTPO;
[Asn157, Asn164] hTPO;
[Asn162, Ser164] hTPO;
[Asn162, Thr164] hTPO;
[Asn153, Ser155, Asn164] hTPO;
[Asn153, Thr155, Asn164] hTPO;
[Asn159, Ser161, Asn164] hTPO;
[Asn159 , Thr161Asn164] hTPO;
[Asn166, Ser168] hTPO;
[Asn166 , Thr168] hTPO;
and
[Asn164, Asn168] hTPO.

25 more elements

Dependencies are inferred from the claim text.