Nuclear matrix proteins, polynucleotide sequences encoding them, and their use
AssigneeUniversity of Pittsburgh
InventorRobert H. Getzenberg
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Abstract
A novel prostate cancer marker is described that is found in cancerous and normal cells of the prostate in individuals that have prostate cancer but is not found in the prostate of individuals without the disease. In addition, it is present in normal tissue adjacent to the tumor tissue in individuals having prostate cancer. It is, however, absent in the prostate of individuals without the disease. Methods employing the novel prostate cancer marker of the invention to predict the occurrence of the prostate disease, monitor the progression of prostate cancer and effect the treatment of prostate cancer, are also described.
Claims43
A purified protein which is found in cancerous and normal cells of a prostate in individuals that have prostate cancer but is not found in prostate cells of individuals without prostate cancer, wherein an individual is defined as having prostate cancer if a pathologically identified lesion is present within the prostate, or an antigenic fragment thereof.
The recombinant expression vector of claims 27 or 29, wherein said vector is a virus.
Dependencies are inferred from the claim text.