Stable RXR expressing cell line
AssigneeAllergan Sales, Inc.
InventorsJyotirmoy Kusari, Sheila X. Zhou, Hongzhi Liu, Ramilla O. Lewis, Roshantha A. Chandraratna
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Abstract
Stable cell lines which express retinoid receptors and the insulin receptor are prepared and are useful in identifying agonists and antagonists of retinoid receptors. Agonists and antagonists of the RXR receptor can be determined using the cell lines of the invention which are producers of RXR alone; agonists and antagonists of other retinoid receptors can be determined using cell lines transfected with RXR and the desired retinoid receptor.
Claims22
A stable cell line which constitutively and stably expresses both a nucleotide sequence encoding at least one retinoid receptor and a nucleotide sequence encoding an insulin receptor.
Dependencies are inferred from the claim text.