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AssigneeKorea Atomic Energy Research Institute
InventorsKyung Bae Park, Sang Hyun Park, Hui Jeong Gwon, Sun Ju Choi, Byung Chul Shin, Young Don Hong, Sang Mu Choi, Woong Woo Park, Kwang Hee Han, Beom Su Jang
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The present invention relates to a method of preparing technetium or rhenium complex for radiopharmaceuticals, through reaction of pertechnetate or perrhenate with a ligand in the presence of a reducing agent, wherein the reducing agent is a borohydride exchange resin (BER) . The borohydride exchange resin of the present invention has advantages of being stable in a wide range of Ph, including acidic or alkaline condition(Ph 2˜14) and thus being applicable to biological materials as well as being easily removable through filtration when being administrated. Also since the radiolabelled complex is produced under conditions milder than those required for the conventional reducing agents as well as has high radiochemical purity and high labeling efficiency, the conventional reducing agents can be replaced by the BER of the present invention.
A method of preparing technetium or rhenium complexes for radiopharmaceuticals, through reaction of pertechnetate or perrhenate with a ligand in the presence of a reducing agent, wherein the reducing agent is a borohydride exchange resin.
A kit for radiolabelling with technetium or rhenium, comprising a ligand and a borohydride exchange resin.
Dependencies are inferred from the claim text.