US 2003/0226157 A1 · Graft animal model for high induction of papillomas, the propagation of papillomavirus and evaluation of candidate therapeutic agents

Abstract

The present invention relates to a graft animal model for propagating papilloma virus and for evaluating and testing candidate therapeutic agents against papilloma virus. The animal model comprises, a recipient animal engrafted with injured skin graft infected with a host-specific papilloma virus (PV). The grafted skin, having demonstrable papillomas supports the propagation of its host-specific PV. The invention particularly relates to a xenograft animal model for hosting and propagating human papillomavirus (HPV), thereby providing a means for generating infectious and passaging HPV suspensions, and for screening candidate therapeutic agents against HPV. The invention additionally relates to a novel method for generating the xenograft human animal model.

Claims21

Dependent claims

A graft mouse model for improving the rate of induction and formation of human papillomas comprising:

(a) a recipient mouse selected from the group consisting of:
severe combined immuno-deficient (SCID) mice, SCID/beige mice, nude mice, and NIH-nu-bg-xid mice, said mouse being grafted with human foreskin tissue, said foreskin tissue having been meshed prior to said grafting;
and
(b) inoculating said grafted foreskin tissue prior to healing with an inoculum of human papillomavirus,
wherein said grafted foreskin is supported by said recipient mouse and is capable of inducing and sustaining growth of said human papillomavirus and harboring at least one papilloma containing infectious viral particles.

2 more elements

Dependencies are inferred from the claim text.

Graft animal model for high induction of papillomas, the propagation of papillomavirus and evaluation of candidate therapeutic agents

Life of this patent

Graft animal model for high induction of papillomas, the propagation of papillomavirus and evaluation of candidate therapeutic agents

Life of this patent

Abstract

Claims21